The study maps signatures of stressed oligodendrocytes, reactive astrocytes and activated microglia most strongly to plaque rims, but doesn't explain what creates this spatial gradient. Understanding these spatial dynamics could inform therapeutic targeting strategies for limiting lesion expansion. Gap type: unexplained_observation Source paper: Neuronal vulnerability and multilineage diversity in multiple sclerosis. (2019, Nature, PMID:31316211)
Landscape Summary: What drives the spatial restriction of stressed oligodendrocytes and reactive glia to MS plaque rims? is a 0.74 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What drives the spatial restriction of stressed oligodendrocytes and reactive glia to MS plaque rims? — INVOKE-2 (completed)
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