The abstract describes FGF2 as having dual roles - promoting myelination/remyelination while also contributing to neuroinflammation and disease exacerbation. The molecular mechanisms determining these opposing outcomes are not explained, limiting therapeutic targeting strategies. Gap type: unexplained_observation Source paper: Molecular mechanism and the main signaling pathways in the development and progression of multiple sclerosis. (2025, Experimental cell research, PMID:40992569)
Landscape Summary: How does FGF2 simultaneously promote beneficial remyelination and detrimental neuroinflammation in MS? is a 0.8 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does FGF2 simultaneously promote beneficial remyelination and detrimental neuroinflammation in MS? — INVOKE-2 (completed)
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