Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Γ-SECRETASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| AMYLOID-Β | produces | protein | 0.95 |
| APP | cleaves | protein | 0.95 |
| C99 | cleaves | protein | 0.95 |
| AMYLOID BETA | cleaves | protein | 0.95 |
| Alzheimer Disease | involved_in | disease | 0.95 |
| neuron | expressed_in | cell_type | 0.85 |
| LDLR | modifies | protein | 0.80 |
| claudin-5 | cleaves | protein | 0.70 |
| TREM2 cleavage | activates | phenotype | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745
neurodegeneration | 2026-04-12 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
Hypotheses and analyses mentioning Γ-SECRETASE in their description or question text
No additional research found