disease

Alzheimer Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Alzheimer Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1790Connections

0Hypotheses

9Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	AMYLOID-Β, TAU, MTOR, SNCA, MAPT, CASP6, AMBRA1, APP/PS1
Therapeutic Agents	Spautin-1, Gastrodiae Elata, Anti-Aβ Antibodies, Anti-Neuroinflammatory Therapeutics, Donanemab
KG Connections	395 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Alzheimer_Disease["Alzheimer Disease"] -->|"associated"| Molecular_Heterogeneity["Molecular Heterogeneity"]
    style Molecular_Heterogeneity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_Disease["Alzheimer Disease"] -->|"associated"| Blood_Brain_Barrier_Dysfunctio["Blood-Brain Barrier Dysfunction"]
    style Blood_Brain_Barrier_Dysfunctio fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Alzheimer_Disease["Alzheimer Disease"] -->|"associated"| Sex_Differences["Sex Differences"]
    style Sex_Differences fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    APOE["APOE"] -->|"risk factor for"| Alzheimer_Disease["Alzheimer Disease"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APOE__4["APOE*epsilon4"] -->|"risk factor for"| Alzheimer_Disease["Alzheimer Disease"]
    style APOE__4 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AMYLOID__["AMYLOID-Beta"] -->|"associated"| Alzheimer_Disease["Alzheimer Disease"]
    style AMYLOID__ fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TAU["TAU"] -->|"associated"| Alzheimer_Disease["Alzheimer Disease"]
    style TAU fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Ageing["Ageing"] -->|"risk factor for"| Alzheimer_Disease["Alzheimer Disease"]
    style Ageing fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style Alzheimer_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (949)

Target	Relation	Type	Str
Molecular Heterogeneity	associated_with	process	0.95
Premature Senescence	causes	phenotype	0.90
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
Sex Differences	associated_with	phenotype	0.75
HIF1	activates	concept	0.50
EIF2S1	activates	concept	0.50
PGAM5	activates	concept	0.50
RIP3	activates	concept	0.50
RETREG1	activates	concept	0.50
disease	activates	disease	0.50
ENDOTHELIAL	activates	concept	0.50
FRONTOTEMPORAL	activates	concept	0.50
COPD	activates	disease	0.50
SYNUCLEIN	activates	concept	0.50
Reactive Oxygen Species	activates	process	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
disease	interacts_with	disease	0.50
NEURODEGENERATIVE DISEASE	interacts_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-β	interacts_with	concept	0.50
α-SYNUCLEIN	interacts_with	concept	0.50
disease	associated_with	disease	0.50
DMSO	activates	concept	0.50
PRKAA	activates	concept	0.50
Infection	activates	disease	0.50
Proteins	activates	protein	0.50
RAPAMYCIN	activates	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
disease	causes	disease	0.50
AMYLOID-β	associated_with	concept	0.50
NEUROFIBRILLARY TANGLES	associated_with	concept	0.50
STEM CELLS	interacts_with	concept	0.50
FRONTOTEMPORAL	associated_with	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
α-SYNUCLEIN	associated_with	concept	0.50
NEURONS	associated_with	concept	0.50
disease	inhibits	disease	0.50
Cognitive Impairment	inhibits	phenotype	0.50
disease	regulates	disease	0.50
NEURODEGENERATIVE DISEASE	activates	concept	0.50
FRONTOTEMPORAL	regulates	concept	0.50
NEURODEGENERATIVE DISEASE	regulates	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
Proteostasis	interacts_with	process	0.50
AUTOPHAGOSOME	interacts_with	concept	0.50
Microbiota	activates	process	0.50

Incoming (841)

Source	Relation	Type	Str
Amyloid Probability Score 2	biomarker_for	biomarker	0.98
Blood Test	biomarker_for	biomarker	0.98
APOE	risk_factor_for	gene	0.95
APOE*ε4	risk_factor_for	biomarker	0.95
AMYLOID-Β	associated_with	protein	0.95
TAU	associated_with	protein	0.95
Ageing	risk_factor_for	process	0.95
Amyloid-β	biomarker_for	biomarker	0.95
Amyloid-β Accumulation	contributes_to	phenotype	0.95
Amyloid-Beta Accumulation	contributes_to	phenotype	0.95
BETA-AMYLOID	biomarker_for	protein	0.95
TAU	biomarker_for	protein	0.95
Neuritic Plaques	associated_with	phenotype	0.95
Neurofibrillary Tangles	associated_with	phenotype	0.95
Amyloid-beta	biomarker_for	biomarker	0.95
Neuroinflammation	contributes_to	process	0.95
Microglia	contributes_to	cell_type	0.95
Immune Activation	contributes_to	process	0.95
MAPT	causes	gene	0.95
APOE	protects_against	gene	0.95
Amyloid-Beta Plaque Deposition	biomarker_for	biomarker	0.95
Phosphorylated Tau 217	biomarker_for	biomarker	0.95
AMYLOID BETA	involved_in	protein	0.95
TAU	involved_in	protein	0.95
Oxidative Stress	contributes_to	process	0.95
Microglial Phagocytosis	causes	process	0.95
Anti-Aβ Antibodies	treats	drug	0.95
AMYLOID-BETA	associated_with	protein	0.95
APOE ε4	risk_factor_for	protein	0.95
Aβ42:Aβ40 Ratio	biomarker_for	biomarker	0.95
Phosphorylated Tau at Threonine 181	biomarker_for	biomarker	0.95
Γ-SECRETASE	involved_in	enzyme	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
MAPT	biomarker_for	protein	0.95
Amyloid-Beta 42	biomarker_for	protein	0.95
Amyloid-Beta 40	biomarker_for	protein	0.95
P-Tau217	biomarker_for	biomarker	0.95
APOE ε4 Allele	risk_factor_for	biomarker	0.95
Macrophages	contributes_to	cell_type	0.95
Cellular Senescence	contributes_to	process	0.95
Donanemab	treats	drug	0.95
Amyloid Reduction	therapeutic_target	mechanism	0.95
ISG15	implicated_in	gene	0.95
Amyloid-Beta 42/40 Ratio	biomarker_for	biomarker	0.92
APOE*ε2	protects_against	biomarker	0.90
Synapse-Related Genes	associated_with	pathway	0.90
Poor Cognitive Function	associated_with	phenotype	0.90
Neurodegeneration	contributes_to	process	0.90
Astrogliosis	associated_with	process	0.90
MAPT	associated_with	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (9)

Scientific analyses that reference this entity

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 0 hypotheses

Quantitative proteomics of the aging synapse in early Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Human connectome alterations and network-level dysfunction in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Alzheimer Disease

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Pathway Diagram

Outgoing (949)

Incoming (841)

Targeting Hypotheses (0)

Mentioning Analyses (9)

Trans-synaptic tau spreading and propagation mechanisms in AD

Quantitative proteomics of the aging synapse in early Alzheimer disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Extracellular vesicle biomarkers for early AD detection

Related Papers (0)

Alzheimer Disease

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

Therapeutics

Neurons — Cell Type Hierarchy

Pathway Diagram

Outgoing (949)

Incoming (841)

Targeting Hypotheses (0)

Mentioning Analyses (9)

Trans-synaptic tau spreading and propagation mechanisms in AD

Quantitative proteomics of the aging synapse in early Alzheimer disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Extracellular vesicle biomarkers for early AD detection

Related Papers (0)