Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AAV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AAV |
| Summary | China-based biotechnology company developing AAV gene therapies for rare neurological diseases, with a CDKL5 deficiency program in IND-enabling stage. |
| Key Genes/Proteins | NDNF, BDNF, APOE, GDNF, Cas9 |
| Related Diseases | Rodents, Macaque |
| Related Pathways | Descending Motor Pathways |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
AAV["AAV"] -->|"associated"| Rodents["Rodents"]
style Rodents fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
AAV["AAV"] -->|"associated"| Macaque["Macaque"]
style Macaque fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
AAV["AAV"] -->|"targets"| NDNF["NDNF"]
style NDNF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
AAV["AAV"] -->|"targets"| Brain["Brain"]
style Brain fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
AAV["AAV"] -->|"transports"| BDNF["BDNF"]
style BDNF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
AAV["AAV"] -->|"transports"| APOE["APOE"]
style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
AAV["AAV"] -->|"transports"| GDNF["GDNF"]
style GDNF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style AAV fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Rodents | associated_with | phenotype | 0.90 |
| Macaque | associated_with | phenotype | 0.90 |
| NDNF | targets | protein | 0.90 |
| Rodents | expressed_in | phenotype | 0.90 |
| Macaque | expressed_in | phenotype | 0.90 |
| BDNF | transports | protein | 0.85 |
| APOE | transports | gene | 0.85 |
| GDNF | transports | protein | 0.85 |
| Cas9 | targets | protein | 0.85 |
| Spinal Motor Neurons | targets | cell_type | 0.80 |
| Descending Motor Pathways | targets | pathway | 0.80 |
| DNA | regulates | process | 0.70 |
| nervous system | therapeutic_target | cell_type | 0.70 |
| heart | therapeutic_target | cell_type | 0.70 |
| gene expression | regulates | process | 0.70 |
| gene silencing | activates | process | 0.70 |
| gene editing | activates | process | 0.70 |
| Microglia | targets | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2 R47H Variant Correction — AAV-Mediated Rescue of Commo | 0.452 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
drug delivery | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| Role of TREM2 in neuroinflammation. [PMID:41213496] | Abdulkhaliq AA, Alasiri G, Almoghrabi Y, | Exp Neurol | 2026 | 0 |
| Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649] | Zhang J, St Pierre Schneider B, Muguerza | Am J Physiol Endocrinol Metab | 2026 | 0 |
| Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750] | Yang X, Zhao Y, Liu W, Feng J, Wu X et a | J Ethnopharmacol | 2026 | 0 |
| Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929] | Mateus-Tique J, Lakshmi A, Singh B, Iyer | Cancer Cell | 2026 | 0 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393] | Feiten AF, Dahm K, Schlepckow K, van Len | Nat Commun | 2026 | 0 |
| Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928] | Xia P, Shuang S, Fu D, Liu L, Yang D et | NPJ Precis Oncol | 2026 | 0 |
| Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086] | Zhao Q, Huang R, Wang C, Hu J, Nie R et | Cancer Cell | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876] | Chen F, Xue Y, Ma X, Chen L, Shao Z et a | Adv Sci (Weinh) | 2026 | 0 |
| Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643] | Unknown | Advanced materials (Deerfield | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268] | ["Srivastav Jyotsna", "Sharma Sachin"] | Frontiers in medicine | 2025 | 0 |
| Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376] | Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa | 1993 | 0 |