gene

GDNF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

896Connections

1Hypotheses

9Analyses

50Outgoing

50Incoming

Summary

Page for GDNF — Glial Cell Line-Derived Neurotrophic Factor

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🧬 Gene Info

Gene Symbol	GDNF
Aliases	Glial Cell Line-Derived Neurotrophic Factor
Chromosome	5q32
Protein Family	GDNF family (TGF-β superfamily)
Function	Maintains tyrosine hydroxylase expression
Primary Expression	Secreted, Extracellular space
Subcellular Localization	Secreted, Extracellular space
Molecular Weight	15 kDa
Pathways	PI3K, MAPK, TGF-β
UniProt ID	P39905
GeneCards	GDNF
Human Protein Atlas	GDNF
GFRα1	Co-receptor essential for GDNF signaling specificity
RET	Receptor tyrosine kinase required for GDNF-mediated activation
Neurturin	GDNF family member with overlapping but distinct biological roles
Associated Diseases	ALS, APOPTOSIS, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compounds	levodopa, trehalose, rapamycin
Interactions	GFRAL, BDNF, GLP1R, SHH, ADCY3, LMX1A
SciDEX Hypotheses	GDNF Gradient Establishment by Schwann Cells Enabl
KG Connections	779 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GDNF — AlphaFold P39905 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Pathway Diagram

flowchart TD
    GDNF["GDNF"] -.->|"inhibits"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"activates"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"interacts with"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"therapeutic target"| Dopamine["Dopamine"]
    Dopamine["Dopamine"] -->|"interacts with"| GDNF["GDNF"]
    GDNF["GDNF"] -.->|"inhibits"| Als["Als"]
    GDNF["GDNF"] -->|"activates"| Als["Als"]
    GDNF["GDNF"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
    GDNF["GDNF"] -->|"associated with"| TNF["TNF"]
    GDNF["GDNF"] -->|"associated with"| MITOCHONDRIA["MITOCHONDRIA"]
    GDNF["GDNF"] -->|"associated with"| TAU["TAU"]
    GDNF["GDNF"] -->|"associated with"| GFAP["GFAP"]
    style GDNF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Dopamine fill:#006494,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style NEURODEGENERATION fill:#006494,stroke:#333,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MITOCHONDRIA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TAU fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GFAP fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (592)

Target	Relation	Type	Str
Neural Stem Cell Differentiation	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
neurotrophin signaling	participates_in	pathway	0.85
PARKINSON'S DISEASE	treats	disease	0.85
astrocytes	expressed_in	cell_type	0.85
RET	activates	gene	0.80
brain health	promotes	biological_process	0.80
neurons	activates	cell_type	0.80
neurons	protects_against	cell_type	0.80
neurons	associated_with	cell_type	0.80
Parkinson's disease	activates	disease	0.80
NEURODEGENERATION	protects_against	disease	0.75
IL-10	activates	gene	0.75
unfolded protein response	participates_in	pathway	0.75
TGF-beta signaling	participates_in	pathway	0.75
Dopamine	inhibits	entity	0.70
Dopamine	activates	entity	0.70
Dopamine	interacts_with	entity	0.70
Dopamine	therapeutic_target	entity	0.70
neurodegeneration	interacts_with	disease	0.70
HDAC1	inhibits	gene	0.70
brainstem	expressed_in	brain_region	0.70
RET	regulates	gene	0.70
neurodegeneration	regulates	disease	0.70
GFRA1	interacts_with	gene	0.70
NGF	regulates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
BRAINSTEM	activates	brain_region	0.70
BRAINSTEM	treats	brain_region	0.70
neural stem cells	activates	cell_type	0.70
dopaminergic neurons	protects_against	cell_type	0.70
neurons	regulates	cell_type	0.70
T cells	expressed_in	cell_type	0.70
TNF	associated_with	gene	0.65
TAU	associated_with	gene	0.65
GFAP	associated_with	gene	0.65
NGF	associated_with	gene	0.65
neuroinflammation	activates	disease	0.65
HSP70	protects_against	gene	0.65
astrocyte	co_discussed	concept	0.65
neuroinflammation	co_discussed	concept	0.65
PI3K	co_discussed	gene	0.65
TREM2	co_discussed	gene	0.65
STAT3	co_discussed	gene	0.65
autophagy	co_discussed	concept	0.65
AKT	protects_against	gene	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
NEURODEGENERATION	associated_with	concept	0.65
MITOCHONDRIA	associated_with	gene	0.65

Incoming (304)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	0.96
h-47ab2be5	targets_gene	hypothesis	0.90
BDNF	protects_against	gene	0.85
AAV	transports	drug	0.85
BDNF	associated_with	gene	0.82
AMYLOID	associated_with	gene	0.82
GLP-1	upregulates	protein	0.80
Multiplexed Base Editing	activates	mechanism	0.80
Dopamine	interacts_with	entity	0.70
BDNF	expressed_in	gene	0.70
TREHALOSE	protects_against	drug	0.70
TREHALOSE	destabilizes	drug	0.70
ASTROCYTE	protects_against	cell_type	0.70
BDNF	inhibits	gene	0.66
BDNF	activates	gene	0.66
ALS	associated_with	gene	0.66
APOPTOSIS	associated_with	gene	0.66
AQP4	associated_with	gene	0.65
CNTF	associated_with	gene	0.65
APP	associated_with	gene	0.65
AKT	co_discussed	gene	0.65
HEDGEHOG SIGNALING	protects_against	pathway	0.65
AUTOPHAGY	associated_with	gene	0.65
ASTROCYTE	associated_with	gene	0.65
AMPK	associated_with	gene	0.65
INFLAMMATION	regulates	phenotype	0.65
NEURONS	treats	cell_type	0.65
rapamycin	targets	drug	0.65
STRIATUM	activates	brain_region	0.65
ERK	activates	gene	0.65
MICROGLIA	regulates	cell_type	0.65
GLP1R	inhibits	gene	0.60
GFRAL	inhibits	gene	0.60
APP	inhibits	gene	0.60
HDAC6	activates	gene	0.60
RET	regulates	gene	0.60
GFRAL	activates	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
VIMENTIN	expressed_in	gene	0.60
NGF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
ASCL1	activates	gene	0.60
BDNF	contributes_to	gene	0.60
NGF	contributes_to	gene	0.60
NGF	associated_with	gene	0.60
TLR4	activates	gene	0.60
NLRP3	inhibits	gene	0.60
OVERVIEW	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GDNF Gradient Establishment by Schwann Cells Enables Motor R	0.585	neurodegeneration	What molecular mechanisms enable functio

Mentioning Analyses (9)

Scientific analyses that reference this entity

What molecular mechanisms enable functional recovery and muscle re-innervation a

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.658

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GDNF

Understanding Entity Pages

Summary

Wiki Pages (21)

GDNF (Redirect)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Pathway Diagram

Outgoing (592)

Incoming (304)

Targeting Hypotheses (1)

Mentioning Analyses (9)

What molecular mechanisms enable functional recovery and muscle re-innervation a

Epigenetic reprogramming in aging neurons

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Neuroinflammation resolution mechanisms and pro-resolving mediators

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (0)

GDNF

Understanding Entity Pages

Summary

Wiki Pages (21)

GDNF (Redirect)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

PD Combination Therapy Matrix

nimodipine-als

Neuroresilience Mechanisms and Evidence

Therapeutics

neuroinflammation

CBS/PSP Treatment Rankings

Multiple System Atrophy

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

Astrocyte Reactivity Mechanism

Growth Factor Therapies

Pathway Diagram

Outgoing (592)

Incoming (304)

Targeting Hypotheses (1)

Mentioning Analyses (9)

What molecular mechanisms enable functional recovery and muscle re-innervation a

Epigenetic reprogramming in aging neurons

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Neuroinflammation resolution mechanisms and pro-resolving mediators

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (0)