gene

GDNF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

848Connections

2Hypotheses

10Analyses

50Outgoing

50Incoming

0Experiments

12Debates

Summary

Page for GDNF — Glial Cell Line-Derived Neurotrophic Factor

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🧬 Gene Info

Gene Symbol	GDNF
Aliases	Glial Cell Line-Derived Neurotrophic Factor
Protein Family	GDNF family (TGF-β superfamily)
Function	Maintains tyrosine hydroxylase expression
Primary Expression	Secreted, Extracellular space
Subcellular Localization	Secreted, Extracellular space
Molecular Weight	15 kDa
Pathways	PI3K, MAPK, TGF-β
UniProt ID	P39905
GeneCards	GDNF
Human Protein Atlas	GDNF
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES
Known Drugs/Compounds	levodopa, rapamycin, trehalose
Interactions	ACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER
SciDEX Hypotheses	GDNF Gradient Establishment by Schwann Cells Enabl
KG Connections	734 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GDNF — AlphaFold P39905 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GDNF["GDNF"] -.->|"inhibits"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"activates"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"interacts with"| Dopamine["Dopamine"]
    GDNF["GDNF"] -->|"therapeutic target"| Dopamine["Dopamine"]
    Dopamine["Dopamine"] -->|"interacts with"| GDNF["GDNF"]
    GDNF["GDNF"] -.->|"inhibits"| Als["Als"]
    GDNF["GDNF"] -->|"activates"| Als["Als"]
    GDNF["GDNF"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
    GDNF["GDNF"] -->|"associated with"| TNF["TNF"]
    GDNF["GDNF"] -->|"associated with"| MITOCHONDRIA["MITOCHONDRIA"]
    GDNF["GDNF"] -->|"associated with"| TAU["TAU"]
    GDNF["GDNF"] -->|"associated with"| GFAP["GFAP"]
    style GDNF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Dopamine fill:#006494,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style NEURODEGENERATION fill:#006494,stroke:#333,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MITOCHONDRIA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style TAU fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GFAP fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (564)

Target	Relation	Type	Str
Neural Stem Cell Differentiation	regulates	process	0.90
neurons	expressed_in	cell_type	0.90
PARKINSON'S DISEASE	treats	disease	0.85
astrocytes	expressed_in	cell_type	0.85
neurotrophin signaling	participates_in	pathway	0.85
RET	activates	gene	0.80
brain health	promotes	process	0.80
neurons	associated_with	cell_type	0.80
Parkinson's disease	activates	disease	0.80
neurons	activates	cell_type	0.80
neurons	protects_against	cell_type	0.80
NEURODEGENERATION	protects_against	disease	0.75
TGF-beta signaling	participates_in	pathway	0.75
IL-10	activates	gene	0.75
unfolded protein response	participates_in	pathway	0.75
Dopamine	interacts_with	entity	0.70
Dopamine	inhibits	entity	0.70
Dopamine	therapeutic_target	entity	0.70
Dopamine	activates	entity	0.70
brainstem	expressed_in	brain_region	0.70
neural stem cells	activates	cell_type	0.70
T cells	expressed_in	cell_type	0.70
dopaminergic neurons	protects_against	cell_type	0.70
neurons	regulates	cell_type	0.70
GFRA1	interacts_with	gene	0.70
BRAINSTEM	treats	brain_region	0.70
neurodegeneration	regulates	disease	0.70
NGF	regulates	gene	0.70
BRAINSTEM	activates	brain_region	0.70
RET	regulates	gene	0.70
neurodegeneration	interacts_with	disease	0.70
oxidative stress response	participates_in	pathway	0.70
HDAC1	inhibits	gene	0.70
RET signaling	activates	pathway	0.70
als	targets	disease	0.70
Als	inhibits	disease	0.65
ALS	regulates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
INFLAMMATION	treats	phenotype	0.65
Diabetes	regulates	disease	0.65
neuroinflammation	activates	disease	0.65
Tumor	regulates	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Glioma	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Obesity	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Huntington	associated_with	disease	0.65

Incoming (284)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	0.96
h-47ab2be5	targets	hypothesis	0.90
AAV	transports	drug	0.85
BDNF	protects_against	gene	0.85
AMYLOID	associated_with	gene	0.82
BDNF	associated_with	gene	0.82
GLP-1	upregulates	protein	0.80
Dopamine	interacts_with	entity	0.70
TREHALOSE	protects_against	drug	0.70
TREHALOSE	associated_with	drug	0.70
ASTROCYTE	protects_against	cell_type	0.70
BDNF	expressed_in	gene	0.70
BDNF	inhibits	gene	0.66
BDNF	activates	gene	0.66
ALS	associated_with	gene	0.66
APOPTOSIS	associated_with	gene	0.66
AUTOPHAGY	associated_with	gene	0.65
AMPK	associated_with	gene	0.65
NEURONS	treats	cell_type	0.65
INFLAMMATION	regulates	phenotype	0.65
ASTROCYTE	associated_with	gene	0.65
HEDGEHOG SIGNALING	protects_against	pathway	0.65
ERK	activates	gene	0.65
rapamycin	targets	drug	0.65
MICROGLIA	regulates	cell_type	0.65
CNTF	associated_with	gene	0.65
APP	associated_with	gene	0.65
STRIATUM	activates	brain_region	0.65
AKT	co_discussed	gene	0.65
AQP4	associated_with	gene	0.65
APP	inhibits	gene	0.60
CDNF	expressed_in	gene	0.60
CANCER	regulates	gene	0.60
CDNF	associated_with	gene	0.60
GFRAL	inhibits	gene	0.60
CDNF	protects_against	gene	0.60
HIF	regulates	gene	0.60
CNTF	protects_against	gene	0.60
CXCR4	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
TLR4	activates	gene	0.60
NLRP3	inhibits	gene	0.60
NGF	associated_with	gene	0.60
GBA1	interacts_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
GFRAL	associated_with	gene	0.60
TAU	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GDNF Gradient Establishment by Schwann Cells Enables Motor R	0.610	neurodegeneration	What molecular mechanisms enable functio
GDNF-RET Trophic Signaling Deficit	0.530	neurodegeneration	Which specific factors in conditioned me

Mentioning Analyses (10)

Scientific analyses that reference this entity

Which specific factors in conditioned medium from healthy astrocytes rescue moto

neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.895

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.710

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (12)

Multi-agent debates referencing this entity

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

closed · Rounds: 4 · Score: 0.46 · 2026-04-27

Which specific factors in conditioned medium from healthy astrocytes rescue moto

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GDNF in their description or question text

No additional research found

GDNF

Understanding Entity Pages

Summary

Wiki Pages (21)

Glial Cell Derived Neurotrophic Factor (GDNF)

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

Synthetic Gene Circuit for Feedback-Controlled GDNF Delivery

GDNF Neurons

GDNF Signaling Pathway in Neurodegeneration

PD Neurotrophin/GDNF Delivery Companies

Pathway Diagram

Outgoing (564)

Incoming (284)

Targeting Hypotheses (2)

Mentioning Analyses (10)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

Epigenetic reprogramming in aging neurons

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Neuroinflammation resolution mechanisms and pro-resolving mediators

Digital biomarkers and AI-driven early detection of neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Experiments (0)

Related Papers (0)

Debates (12)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Which specific factors in conditioned medium from healthy astrocytes rescue moto

Epigenetic reprogramming in aging neurons

Astrocyte reactivity subtypes in neurodegeneration

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Mitochondrial transfer between astrocytes and neurons

Related Research

GDNF

Understanding Entity Pages

Summary

Wiki Pages (21)

Glial Cell Derived Neurotrophic Factor (GDNF)

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

Synthetic Gene Circuit for Feedback-Controlled GDNF Delivery

GDNF Neurons

GDNF Signaling Pathway in Neurodegeneration

PD Neurotrophin/GDNF Delivery Companies

AB-1005 (REGENERATE-PD) GDNF Gene Therapy Trial

GFRA4 - GDNF Family Receptor Alpha 4

Artemin (ARTN) - GDNF Family Neurotrophic Factor Therapy

Glial Cell Line-Derived Neurotrophic Factor (GDNF) Therapies

Neurotrophic Factor Gene Therapy Programs — GDNF, CDNF, BDNF, Neurturin

GFRα3 Protein - GDNF Family Receptor Alpha 3

GFRα4 Protein - GDNF Family Receptor Alpha 4

GFRA2 - GDNF Family Receptor Alpha 2

GDNF (Glial Cell Line-Derived Neurotrophic Factor) Neurons

AB-1005 GDNF Gene Therapy Long-Term Follow-up Study

AB-1005 (REGENERATE-PD) GDNF Gene Therapy Trial

GFRα2 Protein - GDNF Family Receptor Alpha 2

GDNF Therapy for Parkinson's Disease

GDNF - Neurotrophic Factor Biomarker

GDNF — Glial Cell Line-Derived Neurotrophic Factor

Pathway Diagram

Outgoing (564)

Incoming (284)

Targeting Hypotheses (2)

Mentioning Analyses (10)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

Epigenetic reprogramming in aging neurons

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

Neuroinflammation resolution mechanisms and pro-resolving mediators

Digital biomarkers and AI-driven early detection of neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Blood-brain barrier transport mechanisms for antibody therapeutics

Experiments (0)

Related Papers (0)

Debates (12)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Which specific factors in conditioned medium from healthy astrocytes rescue moto

Epigenetic reprogramming in aging neurons

Astrocyte reactivity subtypes in neurodegeneration

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Mitochondrial transfer between astrocytes and neurons

Related Research