Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ABCA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ABCA4 |
| Key Genes/Proteins | ABCA1, AND, ABCA7 |
| Related Diseases | Stargardt's Disease, Stargardt'S Disease, Macular Degeneration |
| Related Pathways | Cholesterol |
Knowledge base pages for this entity
graph TD
ABCA4["ABCA4"]
ABCA4 -->|"causes"| Stargardt_s_Disease["Stargardt's Disease"]
ABCA4 -->|"causes"| Stargardt_S_Disease["Stargardt'S Disease"]
ABCA4 -->|"expressed in"| Retinal_Pigment_Epithelium["Retinal Pigment Epithelium"]
ABCA4 -->|"expressed in"| Retina["Retina"]
ABCA4 -->|"activates"| Cholesterol["Cholesterol"]
ABCA4 -->|"activates"| Macrophage["Macrophage"]
ABCA4 -->|"activates"| Neuron["Neuron"]
ABCA4 -->|"transports"| AND["AND"]
ABCA7["ABCA7"] -->|"activates"| ABCA4| Target | Relation | Type | Str |
|---|---|---|---|
| Stargardt's Disease | causes | disease | 0.95 |
| Stargardt'S Disease | causes | disease | 0.95 |
| Retinal Pigment Epithelium | expressed_in | cell_type | 0.85 |
| Retina | expressed_in | cell_type | 0.75 |
| Macular Degeneration | associated_with | disease | 0.65 |
| ABCA1 | associated_with | gene | 0.60 |
| Cholesterol | activates | pathway | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| AND | transports | gene | 0.60 |
| ABCA7 | transports | gene | 0.60 |
| ABCA1 | transports | gene | 0.60 |
| Cholesterol | transports | pathway | 0.60 |
| Macrophage | transports | cell_type | 0.60 |
| Neuron | transports | cell_type | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ABCA7 | associated_with | gene | 0.60 |
| Ca1 | expressed_in | brain_region | 0.55 |
| Ca3 | expressed_in | brain_region | 0.55 |
| Macrophage | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||