concept

RETINA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RETINA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

1Hypotheses

1Analyses

31Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	RETINA
Key Genes/Proteins	HDAC3
Related Diseases	GLAUCOMA, NEURODEGENERATION, MITOCHONDRIAL DYSFUNCTION, RETINOPATHY, OBESITY
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RETINA["RETINA"]
    RETINA -.biomarker for.-> Alzheimer_s_Disease["Alzheimer's Disease"]
    RETINA -->|"activates"| SPINAL_CORD["SPINAL CORD"]
    RETINA -->|"implicated in"| T_CELLS["T CELLS"]
    RETINA -->|"causes"| RETINAL_DEGENERATION["RETINAL DEGENERATION"]
    RETINA -->|"activates"| STROKE["STROKE"]
    AMYLOID_BETA["AMYLOID BETA"] -->|"expressed in"| RETINA
    TAU_PROTEIN["TAU PROTEIN"] -->|"expressed in"| RETINA
    HCN1["HCN1"] -->|"expressed in"| RETINA
    P62["P62"] -->|"expressed in"| RETINA
    Complement_System["Complement System"] -->|"expressed in"| RETINA
    ABCA4["ABCA4"] -->|"expressed in"| RETINA
    PARK7["PARK7"] -->|"expressed in"| RETINA
    MICROGLIA["MICROGLIA"] -->|"expressed in"| RETINA

Outgoing (32)

Target	Relation	Type	Str
GLAUCOMA	causes	disease	0.65
NEURODEGENERATION	interacts_with	phenotype	0.65
VISUAL CORTEX	activates	brain_region	0.65
MITOCHONDRIAL DYSFUNCTION	inhibits	phenotype	0.65
RETINOPATHY	causes	disease	0.65
OBESITY	interacts_with	disease	0.65
GABA	inhibits	phenotype	0.65
NEURONS	produces	cell_type	0.65
NEURONS	causes	cell_type	0.65
AMYLOID	targets	protein	0.60
HDAC3	associated_with	gene	0.50
AGING	associated_with	phenotype	0.50
GABA	associated_with	phenotype	0.50
ALS	associated_with	disease	0.50
MOG	associated_with	gene	0.50
TREGS	associated_with	cell_type	0.50
NLRP3	associated_with	gene	0.45
CORTEX	associated_with	brain_region	0.45
AQP4	associated_with	gene	0.45
TAU	associated_with	protein	0.45
CGAS	associated_with	gene	0.45
STING	associated_with	gene	0.45
VISUAL CORTEX	associated_with	brain_region	0.45
CSF	associated_with	phenotype	0.45
P38	associated_with	gene	0.45
P2RX7	associated_with	gene	0.45
HK2	associated_with	gene	0.45
SPINAL CORD	activates	brain_region	0.35
T CELLS	implicated_in	cell_type	0.35
RETINAL DEGENERATION	causes	disease	0.35
STROKE	activates	disease	0.35

Incoming (80)

Source	Relation	Type	Str
HCN1	expressed_in	entity	0.90
INFLAMMATION	protects_against	phenotype	0.65
ALZHEIMER	activates	disease	0.65
HDAC3	protects_against	gene	0.65
HDAC3	regulates	gene	0.65
GABA	regulates	phenotype	0.65
MITOPHAGY	stabilizes	phenotype	0.60
TREGS	targets	cell_type	0.60
AQP4	implicated_in	gene	0.55
ALZHEIMER'S DISEASE	associated_with	disease	0.50
MICROGLIA	expressed_in	cell_type	0.50
OBESITY	associated_with	disease	0.50
ASTROCYTES	associated_with	cell_type	0.50
DEMYELINATION	associated_with	phenotype	0.50
SYNAPTIC TRANSMISSION	associated_with	phenotype	0.50
NEURON	associated_with	cell_type	0.50
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
COMPLEMENT ACTIVATION	associated_with	phenotype	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
MICROGLIA	associated_with	cell_type	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
APOPTOSIS	associated_with	phenotype	0.45
ALZHEIMER	associated_with	disease	0.45
AMYLOID	associated_with	protein	0.45
INFLAMMATION	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
GLAUCOMA	associated_with	disease	0.45
DIABETES	associated_with	disease	0.45
ASTROCYTE	associated_with	cell_type	0.45
GLIOSIS	associated_with	phenotype	0.45
RETINOPATHY	associated_with	disease	0.45
MACULAR DEGENERATION	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
DEMENTIA	associated_with	disease	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
STROKE	associated_with	disease	0.45
CEREBROSPINAL FLUID	associated_with	phenotype	0.45
CALCIUM SIGNALING	associated_with	pathway	0.45
STING PATHWAY	associated_with	pathway	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
COMPLEMENT	activates	protein	0.35
C1Q	activates	gene	0.35
MULTIPLE SCLEROSIS	biomarker_for	disease	0.35
AQP4	expressed_in	gene	0.35
ASTROCYTES	activates	cell_type	0.35
GLIOSIS	activates	process	0.35
NEURODEGENERATION	implicated_in	process	0.35
INFLAMMATION	implicated_in	process	0.35
GLAUCOMA	implicated_in	disease	0.35

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Retinal Vascular Microcirculation Rescue	0.542	neurodegeneration	Digital biomarkers and AI-driven early d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043]	Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY	Stem Cell Res Ther	2025	1
Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152]	Kan T, He Z, Du J, Xu M, Cui J, Han X, T	J Orthop Translat	2022	1
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989]	Yang H, Lee WS, Kong SJ, Kim CG, Kim JH,	J Clin Invest	2019	1
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-c [PMID:37941480]	["De Coninck S", "De Smedt R", "Linterma	Haematologica	2024	0
Observation of Magic Number Clusters from Thermal Dissociation Molecular Dynamic [PMID:32286071]	["Zhang J", "Bogdanov B", "Parkins A", "	The journal of physical chemis	2020	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling [PMID:30942519]	["Chang Y", "Zhu D", "Guo H", "Yin X", "	Chembiochem : a European journ	2019	0
Layer-specific integration of locomotion and sensory information in mouse barrel [PMID:31197148]	["Ayaz A", "St\u00e4uble A", "Hamada M",	Nature communications	2019	0
Somatic APP gene recombination in Alzheimer's disease and normal neurons. [PMID:30464338]	["Lee M", "Siddoway B", "Kaeser G", "Seg	Nature	2018	0
Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ. [PMID:27737004]	["O'Sullivan S", "Tay M", "Lin J", "Bava	PloS one	2016	0
Experiences With Aggressive Cardiac Rehabilitation in Pediatric Patients Receivi [PMID:27829640]	["Amao R", "Imamura T", "Sawada Y", "End	International heart journal	2016	0
Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follic [PMID:24889290]	Scotti L, Parborell F, Irusta G, De Zuñi	Molecular reproduction and dev	2014	0
PKM2 enters the morpheein academy. [PMID:22405271]	["Semenova G", "Chernoff J"]	Molecular cell	2012	0
Recombinant angiopoietin-1 restores higher-order architecture of growing blood v [PMID:12464667]	Uemura A, Ogawa M, Hirashima M, Fujiwara	The Journal of clinical invest	2002	0

RETINA

Understanding Entity Pages

Wiki Pages (20)

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