gene

ABCA7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

591Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ABCA7
Chromosome	19q13
Function	ABCA7 encodes ATP-binding cassette transporter A7, a member of the ABC transporter family.
Primary Expression	immune cells and the brain, where it plays important roles in lipid transport and cellular homeostasis
Subcellular Localization	and processing of APP, potentially increasing amyloidogenic cleavage pathways
Pathways	Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Nf-Κb
Ensembl ID	ENSG00000064687
GeneCards	ABCA7
Human Protein Atlas	ABCA7
Associated Diseases	ALZHEIMER'S DISEASE, Als, Alzheimer, Atherosclerosis
Interactions	NPY, CASS4, EPHA1, CLU, BIN1, CD33
KG Connections	591 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCA7["ABCA7"] -->|"modulates"| Cholesterol_Transport["Cholesterol Transport"]
    ABCA7["ABCA7"] -->|"associated"| APOE["APOE"]
    ABCA7["ABCA7"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCA7["ABCA7"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ABCA7["ABCA7"] -->|"associated"| TREM2["TREM2"]
    ABCA7["ABCA7"] -->|"associated"| ALZHEIMER["ALZHEIMER"]
    ABCA1["ABCA1"] -->|"associated"| ABCA7["ABCA7"]
    PLCG2["PLCG2"] -->|"associated"| ABCA7["ABCA7"]
    TREM2_1["TREM2"] -->|"regulates"| ABCA7["ABCA7"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"protects against"| ABCA7["ABCA7"]
    style ABCA7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (457)

Target	Relation	Type	Str
ds-f50762b67605	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Macrophages	expressed_in	cell_type	0.95
Alzheimer's Disease	risk_factor_for	disease	0.95
Phospholipid Homeostasis	regulates	process	0.90
Microglial Aβ Clearance	involved_in	process	0.90
Phagocytosis	regulates	process	0.90
APP Processing	modulates	process	0.85
Phagocytosis	mediates	process	0.85
Cholesterol Transport	modulates	process	0.80
Lipid Processing	modulates	process	0.80
cholesterol transport	regulates	process	0.80
Neuropeptide Y	induces	protein	0.80
BDNF	induces	protein	0.80
Oxidized Unsaturated Lipids	transports	compound	0.80
Amyloid-β	transports	compound	0.80
neurons	expressed_in	cell_type	0.80
ATP	interacts_with	gene	0.80
stem cells	expressed_in	cell_type	0.80
APOE	associated_with	gene	0.75
Alzheimer	associated_with	disease	0.75
ABCA1	interacts_with	protein	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
TREM2	associated_with	gene	0.65
TREM2	causes	gene	0.65
NLRP3	co_discussed	gene	0.65
PSEN2	co_discussed	gene	0.65
SNCA	co_discussed	gene	0.65
TBK1	co_discussed	gene	0.65
ATP13A2	co_discussed	gene	0.65
MAPT	co_discussed	gene	0.65
OPTN	co_discussed	gene	0.65
SMPD1	co_discussed	gene	0.65
SQSTM1	co_discussed	gene	0.65
TREM2	co_discussed	gene	0.65
ALZHEIMER	associated_with	gene	0.65
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Als	associated_with	disease	0.65
Inflammation	activates	disease	0.65
ALS	regulates	disease	0.65

Incoming (134)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
AMYLOID	associated_with	protein	0.82
APOE2	interacts_with	protein	0.80
APOE	associated_with	gene	0.74
TREM2	associated_with	gene	0.66
MICROGLIA	associated_with	cell_type	0.66
ABCA1	associated_with	gene	0.65
APP	exacerbates	gene	0.65
AMYLOID	treats	protein	0.65
PLCG2	associated_with	gene	0.60
TREM2	regulates	gene	0.60
PLD3	associated_with	gene	0.60
LPL	regulates	gene	0.60
APOE	regulates	gene	0.60
SORL1	associated_with	gene	0.60
ZCWPW1	activates	gene	0.60
FERMT2	activates	gene	0.60
CELF1	activates	gene	0.60
CR1	associated_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
TYK2	regulates	gene	0.60
PILRA	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
MAF	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
BDNF	activates	gene	0.60
NGFR	activates	gene	0.60
PTK2B	activates	gene	0.60
APOE	activates	gene	0.60
CASS4	activates	gene	0.60
SYK	regulates	gene	0.60
PPARG	regulates	gene	0.60
GRN	associated_with	gene	0.60
GBA	associated_with	gene	0.60
DDX1	associated_with	gene	0.60
ADAM10	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
EPHA1	activates	gene	0.60
CD2AP	activates	gene	0.60
EPHA1	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF Biomarker-Guided ABCA7 Therapeutic Dosing	0.619	neurodegeneration	Why does the V1613M variant reduce amylo
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.619

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ABCA7

Understanding Entity Pages

Wiki Pages (21)

ABCA7 (Redirect)

neuroinflammation

Epigenetic Alterations in Alzheimer's Disease

Amyloid Cascade Pathway

Tauopathies

Amyloid-Beta Aggregation and Plaque Formation

genetics

neurovascular-dysfunction

Amyloid Precursor Protein (APP)

Sporadic Alzheimer's Disease Pathway

Ferroptotic Neurons

epigenetics-neurodegeneration

APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chain

Familial Alzheimer's Disease Genetics

Amyloid-Beta (Aβ)

Tau Pathology Alters Oligodendrocyte Gene Methylation in [Alzheimer's Disease](/diseases/alzheimers-disease)

Microglia

ABCA7 Protein

Sporadic vs Familial Alzheimer's Disease: Comprehensive Comparison

adpd-2026-precision-medicine-genetic-stratification