cell_type

Macrophage

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Macrophage: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2321Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Macrophage is a cell type relevant to neurodegeneration research. Key relationships include: expressed in, mediates, involved in. Connected to 211 entities in the SciDEX knowledge graph.

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🧫 Cell Type Info

Cell Type	Macrophage
Related Genes	MIR-369-3P
Linked Hypotheses	151 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Macrophage["Macrophage"] -->|"mediates"| Apoptotic_Cell_Clearance["Apoptotic Cell Clearance"]
    P2RY12["P2RY12"] -->|"expressed in"| Macrophage["Macrophage"]
    TMEM119["TMEM119"] -->|"expressed in"| Macrophage["Macrophage"]
    GAIN["GAIN"] -->|"expressed in"| Macrophage["Macrophage"]
    MICROGLIA["MICROGLIA"] -->|"expressed in"| Macrophage["Macrophage"]
    style Macrophage fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (435)

Target	Relation	Type	Str
Axonal Loss	contributes_to	process	0.95
Cardiovascular Disease	involved_in	disease	0.95
Inflammatory Response	mediates	process	0.92
Apoptotic Cell Clearance	mediates	process	0.90
ConA-Induced Hepatitis	involved_in	disease	0.90
Intracerebral Hemorrhage	involved_in	disease	0.90
Atherosclerosis	contributes_to	disease	0.90
Multiple Sclerosis	contributes_to	disease	0.90
Inflammatory Pain Resolution	promotes	phenotype	0.90
Myocardial Fibrosis	involved_in	phenotype	0.88
Immune Response	involved_in	process	0.85
Nerve Degeneration	mediates	process	0.85
Nerve Tissue Repair	involved_in	process	0.85
Peripheral Nerve Injury	involved_in	disease	0.85
Coronary Heart Disease	associated_with	disease	0.85
Atherosclerosis	associated_with	disease	0.85
Heart Failure	associated_with	disease	0.85
Myocardial Infarction	involved_in	disease	0.85
Aneurysm	associated_with	disease	0.85
Myocarditis	associated_with	disease	0.85
NLRP3 INFLAMMASOME	expressed_in	protein	0.85
MACROPHAGES	regulates	concept	0.50
MACROPHAGES	activates	concept	0.50
MACROPHAGES	expressed_in	concept	0.50
MACROPHAGES	inhibits	concept	0.50
MACROPHAGES	associated_with	concept	0.50
MACROPHAGES	interacts_with	concept	0.50
Tumor Microenvironment	inhibits	process	0.50
MONOCYTE	associated_with	concept	0.50
MONOCYTES	associated_with	concept	0.50
T CELLS	activates	concept	0.50
MONOCYTE	activates	concept	0.50
MONOCYTES	activates	concept	0.50
disease	activates	disease	0.50
CMKLR1	activates	concept	0.50
Pain	regulates	disease	0.50
Pain	expressed_in	disease	0.50
Infection	expressed_in	disease	0.50
Pain	activates	disease	0.50
NEUTROPHIL	inhibits	cell_type	0.50
NEUTROPHILS	inhibits	concept	0.50
NEUTROPHIL	associated_with	cell_type	0.50
NEURONS	activates	concept	0.50
ISCHEMIC	protects_against	concept	0.50
Pancreatic Cancer	activates	disease	0.50
Pancreatic Cancer	expressed_in	disease	0.50
Interferon Signaling	activates	pathway	0.50
cGAS-STING pathway	activates	pathway	0.50
Pancreatic Cancer	associated_with	disease	0.50
Fatty Liver	activates	disease	0.50

Incoming (1886)

Source	Relation	Type	Str
IFN-γ	activates	entity	0.90
MIR-369-3P	expressed_in	gene	0.90
PAD4	regulates	gene	0.90
Glycolytic Reprogramming	expressed_in	process	0.90
Proinflammatory Genetic Profile	associated_with	phenotype	0.85
Decursin	inhibits	drug	0.80
SIRT6	regulates	gene	0.80
TENASCINC	associated_with	protein	0.80
HIF1A	expressed_in	gene	0.80
Epsins	regulates	gene	0.80
RAB7A	expressed_in	protein	0.75
CCL3	associated_with	protein	0.70
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
RNA	activates	gene	0.60
DEMENTIA	activates	gene	0.60
SPP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GRN	activates	gene	0.60
CTSB	activates	gene	0.60
C1QA	activates	gene	0.60
STROKE	associated_with	gene	0.60
GBM	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
C1QC	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
GAIN	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
HSPG2	interacts_with	gene	0.60
KCNK2	associated_with	gene	0.60
WNT	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
AXON	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
HK2	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (2)

Scientific analyses that reference this entity

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Macrophage

Understanding Entity Pages

Summary

Wiki Pages (20)

Novel Therapy Index

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Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

CLCN10 — Chloride Voltage-Gated Channel 10

TREM2 Microglial Signaling Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

nlrc5-protein

Niemann-Pick Disease Type C (NPC)

Excitotoxicity in Neurodegeneration

Curcumin for Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Multiple Sclerosis (MS)

gba

NF-kB Signaling Pathway in Neurodegeneration