gene

ap2a1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ap2a1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
7Outgoing
4Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolAP2A1
AliasesAdaptor-Related Protein Complex 2 Alpha 1
Chromosome19q13.33
Functionencodes a 977-amino acid protein that serves as the largest subunit of the AP-2 heterotetramer, which also includes beta-2, mu-2, and sigma-2 subunits.
Molecular Weight130 kDa
Amino Acids977 aa
PathwaysAutophagy, Endocytosis
Ensembl IDENSG00000146938
GeneCardsAP2A1
Human Protein AtlasAP2A1
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Alzheimer's Disease

disease · 5265 words

AP2M1 Gene

gene · 3193 words

AP2A2 — Adaptor-Related Protein Complex 2 Subunit Alpha 2

gene · 2303 words

LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

gene · 1463 words

AP2B1 — Adaptor Related Protein Complex 2 Subunit Beta 1

gene · 1174 words

Pathway Diagram

flowchart TD
    N0["AP2A1"]
    N1["AP2M1"]
    N0 -->|"activates"| N1
    N2["AUTOPHAGY"]
    N0 -->|"activates"| N2
    N3["LC3"]
    N0 -->|"activates"| N3
    N4["Autophagy"]
    N0 -->|"activates"| N4
    N5["Endocytosis"]
    N0 -->|"activates"| N5
    N6["AND"]
    N6 -->|"activates"| N0
    N3 -->|"activates"| N0
    N7["neurodegeneration"]
    N0 -->|"implicated in"| N7

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N6 gene

Outgoing (7)

TargetRelationTypeStr
ds-db4a006ea647provides_data_fordataset1.00
AP2M1activatesgene0.60
LC3activatesgene0.60
AUTOPHAGYactivatesgene0.60
Autophagyactivatespathway0.60

Incoming (4)

SourceRelationTypeStr
ds-db4a006ea647data_indataset1.00
LC3activatesgene0.60
ANDactivatesgene0.60
benchmark_ot_ad_answer_key:AP2A1data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found