Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ap2a1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | AP2A1 |
| Aliases | Adaptor-Related Protein Complex 2 Alpha 1 |
| Chromosome | 19q13.33 |
| Function | encodes a 977-amino acid protein that serves as the largest subunit of the AP-2 heterotetramer, which also includes beta-2, mu-2, and sigma-2 subunits. |
| Molecular Weight | 130 kDa |
| Amino Acids | 977 aa |
| Pathways | Autophagy, Endocytosis |
| Ensembl ID | ENSG00000146938 |
| GeneCards | AP2A1 |
| Human Protein Atlas | AP2A1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["AP2A1"]
N1["AP2M1"]
N0 -->|"activates"| N1
N2["AUTOPHAGY"]
N0 -->|"activates"| N2
N3["LC3"]
N0 -->|"activates"| N3
N4["Autophagy"]
N0 -->|"activates"| N4
N5["Endocytosis"]
N0 -->|"activates"| N5
N6["AND"]
N6 -->|"activates"| N0
N3 -->|"activates"| N0
N7["neurodegeneration"]
N0 -->|"implicated in"| N7
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 gene
class N2 gene
class N3 gene
class N4 pathway
class N5 pathway
class N6 gene| Target | Relation | Type | Str |
|---|---|---|---|
| ds-db4a006ea647 | provides_data_for | dataset | 1.00 |
| AP2M1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Endocytosis | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:AP2A1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-db4a006ea647 | data_in | dataset | 1.00 |
| LC3 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:AP2A1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||