Contents

ARH Gene

🧬 Gene Info

Gene Symbol	ARH
Full Name	LDLR Adaptor Protein 1
Chromosome	1p36.22
Protein Type	Adaptor Protein
Function	ARH (also known as LDLRAP1 - LDL Receptor Adaptor Protein 1) encodes an adaptor protein that links the LDL receptor (LDLR) to clathrin-mediated endocytosis.
UniProt ID	[Q9Y2T3](https://www.uniprot.org/uniprot/Q9Y2T3)
Ensembl ID	ENSG00000151552
OMIM	605747
GeneCards	ARH
Human Protein Atlas	ARH
ApoE-mediated transport	astrocytes produce ApoE, neurons uptake cholesterol via LDLR/LRP1
ARH's role	modulates LDLR/LRP1 trafficking, affecting neuronal cholesterol acquisition
ApoE-LDLR axis	ApoE4 isoform (major AD risk factor) binds to LDLR and LRP1; ARH modulates receptor trafficking
Amyloid-beta clearance	LRP1 mediates Aβ uptake and clearance; ARH affects this process
Cholesterol-Aβ interplay	Elevated brain cholesterol accelerates Aβ production; LDLR modulates cholesterol influx
Associated Diseases	Neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

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