Contents

AP2A1 Gene

🧬 Gene Info

Gene Symbol	AP2A1
Aliases	Adaptor-Related Protein Complex 2 Alpha 1
Chromosome	19q13.33
Function	encodes a 977-amino acid protein that serves as the largest subunit of the AP-2 heterotetramer, which also includes beta-2, mu-2, and sigma-2 subunits.
Molecular Weight	130 kDa
Amino Acids	977 aa
Pathways	Autophagy, Endocytosis
Ensembl ID	ENSG00000146938
GeneCards	AP2A1
Human Protein Atlas	AP2A1
AP2A1 (α-adaptin)	The largest subunit, containing the core and ear domains
AP2B1 (β2-adaptin)	Shares structural similarity with AP2A1
N-terminal trunk	Forms the core of the complex, interacting with other AP-2 subunits
Linker region	Flexible region connecting trunk to ear
C-terminal ear (appendage)	Platform for protein-protein interactions
Associated Diseases	neurodegeneration
Interactions	AND, AP2M1, AUTOPHAGY, LC3
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph