gene 1,174 words KG: AP2B1 2026-03-27
kind:genesection:genesstate:published
Contents

AP2B1 — Adaptor Related Protein Complex 2 Subunit Beta 1

🧬 Gene Info
Gene SymbolAP2B1
Full NameAdaptor Related Protein Complex 2 Subunit Beta 1
AliasesBeta-2 subunit of AP-2 complex
Chromosome17q12
Protein FamilyAP-2 complex, clathrin adaptors
Functionis a heterotetrameric adaptor that recognizes cargo proteins at the plasma membrane and recruits clathrin to form clathrin-coated vesicles.
Amino Acids937 aa
UniProt IDP63010
NCBI Gene ID163
Ensembl IDENSG00000091640
OMIM601027
GeneCardsAP2B1
Human Protein AtlasAP2B1
N-terminal trunkInteractions with other AP-2 subunits
Linker regionFlexible connection
Associated DiseasesNeurodegeneration, neurodegeneration:
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (7)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Packard Center for ALS Research
institution · KG edge: expressed_in
TXN — Thioredoxin
gene · KG edge: associated_with
PRDX2 — Peroxiredoxin 2
gene · KG edge: associated_with
PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subuni
gene · KG edge: associated_with
GRB2 — Growth Factor Receptor Bound Protein 2
gene · KG edge: associated_with

Knowledge Graph (9 edges)

AP2B1 associated_with GRB2
AP2B1 associated_with PRDX2
AP2B1 associated_with PIK3C3
AP2B1 expressed_in Als
AP2B1 expressed_in Ms
AP2B1 data_in benchmark_ot_ad_answer_key:AP2B1
NR3C1 associated_with AP2B1
TXN associated_with AP2B1
benchmark_ot_ad_answer_key:AP2B1 data_in AP2B1