Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BBB breakdown: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| cognitive decline | risk_factor_for | phenotype | 0.90 |
| neurodegeneration | causes | disease | 0.70 |
| cognitive decline | causes | phenotype | 0.70 |
| Tau Propagation | causes | phenotype | 0.70 |
| neurodegeneration | risk_factor_for | disease | 0.70 |
| neurodegeneration | associated_with | disease | 0.70 |
| Cognitive decline | associated_with | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| pericyte deficiency | causes | process | 0.90 |
| pericyte damage | causes | process | 0.90 |
| Lps | causes | drug | 0.90 |
| APOE4 | causes | gene | 0.70 |
| LRP1 | protective_against | gene | 0.70 |
| MMP9 | causes | gene | 0.70 |
| systemic LPS | causes | biomarker | 0.70 |
| VSMC autophagy impairment | causes | process | 0.70 |
| pericyte loss | causes | process | 0.70 |
| Pericyte loss | causes | cell_type | 0.70 |
| sPDGFRβ | biomarker_for | biomarker | 0.70 |
| IL6 | causes | cytokine | 0.70 |
| VEGF-A dysregulation | causes | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE4-driven pericyte injury/senescence is an upstream drive | 0.720 | neurodegeneration | Does pericyte senescence drive BBB break |
| Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu | 0.705 | - | What blood-brain barrier permeability ch |
| CSF/Serum NfL Ratio Discriminates Active Transcytosis from P | 0.665 | - | What blood-brain barrier permeability ch |
| P2RY12-driven autophagy impairment in cerebral VSMCs mediate | 0.585 | neurodegeneration | How does P2RY12-mediated VSMC dysfunctio |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.76 · 2026-04-28
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.44 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
Hypotheses and analyses mentioning BBB breakdown in their description or question text
No additional research found