Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BBB integrity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| QAlb | biomarker_for | biomarker | 0.90 |
| pericyte-specific PDGFRβ signaling | regulates | process | 0.70 |
| Liproxstatin-1 | protective_against | drug | 0.70 |
| LRP1 | associated_with | gene | 0.70 |
| APOE4 | impairs | gene | 0.70 |
| Liproxstatin-1 | protects_against | drug | 0.70 |
| endothelial cells | modulates | cell_type | 0.70 |
| astrocyte end-feet | regulates | cell_type | 0.70 |
| tight junction stabilization | protective_against | process | 0.70 |
| PDGFRB+ pericytes | protective_against | cell_type | 0.70 |
| PDGFRβ signaling | regulates | pathway | 0.70 |
| P2RY12 | impairs | gene | 0.70 |
| CLDN5 | regulates | protein | 0.70 |
| MMP-9 | inhibits | enzyme | 0.50 |
| Claudin-5 | protects | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| BBB Integrity Loss Defines Absolute Therapeutic Window Closu | 0.660 | neurodegeneration | What is the optimal therapeutic window f |
| Vascular and Perivascular Cell Type Vulnerability: BBB Integ | 0.566 | neurodegeneration | Cell type vulnerability debate in Alzhei |
| CSF p-tau217 Normalization Requires Intact Synaptic Function | 0.515 | neurodegeneration | - |
| HBOT at 1.5 ATA for 90 days restores BBB integrity by upregu | 0.460 | neurodegeneration | What are the optimal oxygen pressure, du |
| HTR2A-Mediated MMP-9 Suppression Preserves BBB Integrity at | 0.425 | - | What is the minimum effective dose of tr |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745
neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.838
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.73 · 2026-04-25
closed · Rounds: 4 · Score: 0.68 · 2026-04-25
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 4 · Score: 0.63 · 2026-04-22
closed · Rounds: 4 · Score: 0.62 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning BBB integrity in their description or question text
No additional research found