cell_type

endothelial cells

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about endothelial cells: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1267Connections
0Hypotheses
0Analyses
16Outgoing
50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info
Cell Typeendothelial cells
Definition<table class="infobox infobox-celltype">
Key MarkersBMAL1, CD2AP, TDP43, THBS1, AQP1, NTN1, FGF2, MALAT1
Key PathwaysNF-kB signaling, unfolded protein response, ferroptosis, autophagy pathway, complement cascade
Associated Diseasesaging, diabetes, stroke, Hepatic Ischemia-Reperfusion Injury, Alzheimer'S Disease, ALS
Linked Hypotheses82 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

CBS/PSP Supplements Guide

therapeutic · 6929 words

Pathway Diagram

graph TD
    endothelial_cells["endothelial cells"] -->|"activates"| Alzheimer_s_disease["Alzheimer's disease"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    endothelial_cells["endothelial cells"] -->|"activates"| Parkinson_s_disease["Parkinson's disease"]
    style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    endothelial_cells["endothelial cells"] -->|"activates"| ALS["ALS"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    endothelial_cells["endothelial cells"] -->|"associated"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    endothelial_cells["endothelial cells"] -->|"interacts"| neuroinflammation["neuroinflammation"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    endothelial_cells["endothelial cells"] -->|"activates"| phagocytosis["phagocytosis"]
    style phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    endothelial_cells["endothelial cells"] -->|"activates"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Alzheimer_s_disease_1["Alzheimer's disease"] -->|"affects"| endothelial_cells["endothelial cells"]
    style Alzheimer_s_disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| endothelial_cells["endothelial cells"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    aging["aging"] -->|"affects"| endothelial_cells["endothelial cells"]
    style aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    diabetes["diabetes"] -->|"affects"| endothelial_cells["endothelial cells"]
    style diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| endothelial_cells["endothelial cells"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style endothelial_cells fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (276)

TargetRelationTypeStr
blood-brain barrierinvolved_inprocess0.95
LRP1expressed_ingene0.90
Alzheimer's diseaseactivatesdisease0.80
blood-brain barrieractive_inpathway0.75
oxidative stress responseactive_inpathway0.65

Incoming (991)

SourceRelationTypeStr
Alzheimer's diseaseaffectsdisease0.90
NF-kB signalingactive_inpathway0.90
agingaffectsdisease0.90
diabetesaffectsdisease0.90
unfolded protein responseactive_inpathway0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found