Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about endothelial cells: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | endothelial cells |
| Definition | <table class="infobox infobox-celltype"> |
| Key Markers | BMAL1, CD2AP, TDP43, THBS1, AQP1, NTN1, FGF2, MALAT1 |
| Key Pathways | NF-kB signaling, unfolded protein response, ferroptosis, autophagy pathway, complement cascade |
| Associated Diseases | aging, diabetes, stroke, Hepatic Ischemia-Reperfusion Injury, Alzheimer'S Disease, ALS |
| Linked Hypotheses | 82 hypotheses |
Knowledge base pages for this entity
graph TD
endothelial_cells["endothelial cells"] -->|"activates"| Alzheimer_s_disease["Alzheimer's disease"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
endothelial_cells["endothelial cells"] -->|"activates"| Parkinson_s_disease["Parkinson's disease"]
style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
endothelial_cells["endothelial cells"] -->|"activates"| ALS["ALS"]
style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
endothelial_cells["endothelial cells"] -->|"associated"| ferroptosis["ferroptosis"]
style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
endothelial_cells["endothelial cells"] -->|"interacts"| neuroinflammation["neuroinflammation"]
style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
endothelial_cells["endothelial cells"] -->|"activates"| phagocytosis["phagocytosis"]
style phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
endothelial_cells["endothelial cells"] -->|"activates"| neurodegeneration["neurodegeneration"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Alzheimer_s_disease_1["Alzheimer's disease"] -->|"affects"| endothelial_cells["endothelial cells"]
style Alzheimer_s_disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
NF_kB_signaling["NF-kB signaling"] -->|"active in"| endothelial_cells["endothelial cells"]
style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
aging["aging"] -->|"affects"| endothelial_cells["endothelial cells"]
style aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
diabetes["diabetes"] -->|"affects"| endothelial_cells["endothelial cells"]
style diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
unfolded_protein_response["unfolded protein response"] -->|"active in"| endothelial_cells["endothelial cells"]
style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
style endothelial_cells fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| blood-brain barrier | involved_in | process | 0.95 |
| LRP1 | expressed_in | gene | 0.90 |
| Alzheimer's disease | activates | disease | 0.80 |
| blood-brain barrier | active_in | pathway | 0.75 |
| oxidative stress response | active_in | pathway | 0.65 |
| Parkinson's disease | activates | disease | 0.60 |
| ALS | activates | disease | 0.60 |
| ferroptosis | associated_with | process | 0.60 |
| neuroinflammation | interacts_with | disease | 0.60 |
| phagocytosis | activates | process | 0.60 |
| ferroptosis | regulates | process | 0.60 |
| Alzheimer's disease | associated_with | disease | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| gut-brain axis | active_in | pathway | 0.55 |
| circadian regulation | active_in | pathway | 0.55 |
| PI3K-AKT-mTOR signaling | active_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | affects | disease | 0.90 |
| NF-kB signaling | active_in | pathway | 0.90 |
| aging | affects | disease | 0.90 |
| diabetes | affects | disease | 0.90 |
| unfolded protein response | active_in | pathway | 0.90 |
| stroke | affects | disease | 0.90 |
| VEGF | expressed_in | gene | 0.90 |
| TNF | expressed_in | gene | 0.90 |
| nitric oxide | released_by | neurotransmitter | 0.90 |
| BECN1 | activates | gene | 0.80 |
| ROS | activates | gene | 0.80 |
| BECN1 | regulates | gene | 0.80 |
| PI3K | activates | gene | 0.80 |
| ferroptosis | active_in | pathway | 0.80 |
| neuroinflammation | affects | disease | 0.80 |
| VEGF | associated_with | gene | 0.80 |
| TNF | activates | gene | 0.80 |
| autophagy pathway | active_in | pathway | 0.80 |
| complement cascade | active_in | pathway | 0.80 |
| neurodegeneration | affects | disease | 0.80 |
| pyroptosis | active_in | pathway | 0.80 |
| VEGF | regulates | gene | 0.80 |
| DNA | expressed_in | gene | 0.80 |
| BECN1 | expressed_in | gene | 0.80 |
| PI3K | expressed_in | gene | 0.80 |
| VEGFA | expressed_in | gene | 0.80 |
| NETS | induces | process | 0.80 |
| TGF | expressed_in | gene | 0.80 |
| AND | expressed_in | gene | 0.80 |
| CD31 | expressed_in | gene | 0.80 |
| APOE | expressed_in | gene | 0.80 |
| RAGE | expressed_in | gene | 0.80 |
| IFN | expressed_in | gene | 0.80 |
| WNT | expressed_in | gene | 0.80 |
| MET | expressed_in | gene | 0.75 |
| Piezo1 | expressed_in | protein | 0.70 |
| STING1 | activates | gene | 0.70 |
| NLRP3 | activates | gene | 0.70 |
| AMPK | activates | gene | 0.70 |
| DNA | activates | gene | 0.70 |
| ATG | activates | gene | 0.70 |
| SQSTM1 | activates | gene | 0.70 |
| LC3 | activates | gene | 0.70 |
| necroptosis | active_in | pathway | 0.70 |
| STING1 | regulates | gene | 0.70 |
| AMPK | regulates | gene | 0.70 |
| ATG | regulates | gene | 0.70 |
| SQSTM1 | regulates | gene | 0.70 |
| LC3 | regulates | gene | 0.70 |
| ROS | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||