Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BI-HTFR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BI-HTFR1 |
Knowledge base pages for this entity
graph TD
BI_HTFR1["BI-HTFR1"]
BI_HTFR1 -->|"binds"| Transferrin_Receptor_1["Transferrin Receptor 1"]
BI_HTFR1 -->|"targets"| Central_Nervous_System["Central Nervous System"]
BI_HTFR1 -->|"binds"| TFRC["TFRC"]
BI_HTFR1 -->|"mediates"| Central_Nervous_System_Gene_De["Central Nervous System Gene Delivery"]
BI_HTFR1 -->|"upregulates"| Glucocerebrosidase["Glucocerebrosidase"]
BI_HTFR1 -->|"transports"| Blood_Brain_Barrier["Blood-Brain Barrier"]
BI_HTFR1 -->|"targets"| GBA1["GBA1"]| Target | Relation | Type | Str |
|---|---|---|---|
| Transferrin Receptor 1 | binds | protein | 0.98 |
| Central Nervous System | mediates | brain_region | 0.98 |
| GBA1 | associated_with | gene | 0.98 |
| Central Nervous System | targets | cell_type | 0.96 |
| Central Nervous System | mediates | cell_type | 0.95 |
| Central Nervous System Gene Delivery | mediates | process | 0.95 |
| Brain Endothelial Cells | transports | cell_type | 0.95 |
| CNS gene expression | upregulates | process | 0.95 |
| Glucocerebrosidase | upregulates | enzyme | 0.93 |
| Blood-Brain Barrier | transports | cell_type | 0.92 |
| GBA1 | targets | gene | 0.90 |
| TfR1 | binds | receptor | 0.90 |
| CNS | mediates | biological_process | 0.90 |
| GBA1 | targets | gene | 0.90 |
| brain endothelial cells | associated_with | cell_type | 0.90 |
| glucocerebrosidase activity | upregulates | process | 0.90 |
| AAV9 | associated_with | drug | 0.88 |
| AAV9 | associated_with | drug | 0.85 |
| Gaucher Disease | treats | disease | 0.85 |
| AAV9 | upregulates | drug | 0.85 |
| Gaucher Disease | treats | disease | 0.85 |
| Gaucher Disease | therapeutic_target | disease | 0.85 |
| Parkinson's Disease | therapeutic_target | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||