concept

CENTRAL NERVOUS SYSTEM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CENTRAL NERVOUS SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

366Connections

0Hypotheses

2Analyses

11Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CENTRAL NERVOUS SYSTEM
Key Genes/Proteins	MAP6, IDH1, AQUAPORIN-4, AQP4, STROKE
Related Diseases	TUMOR, Autoimmune, disease

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    CENTRAL_NERVOUS_SYSTEM -->|"modulates"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    CENTRAL_NERVOUS_SYSTEM -->|"modulates"| Glioblastoma_Multiforme["Glioblastoma Multiforme"]
    CENTRAL_NERVOUS_SYSTEM -->|"expressed in"| Autophagy["Autophagy"]
    GPR37["GPR37"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    BI_hTFR1["BI-hTFR1"] -->|"mediates"| CENTRAL_NERVOUS_SYSTEM
    AQP4["AQP4"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    PIEZO1["PIEZO1"] -->|"involved_in"| CENTRAL_NERVOUS_SYSTEM
    Gut_Microbiota["Gut Microbiota"] -->|"modulates"| CENTRAL_NERVOUS_SYSTEM
    Gut_Brain_Axis["Gut-Brain Axis"] -->|"mediates"| CENTRAL_NERVOUS_SYSTEM
    Microglia["Microglia"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"] -->|"interacts"| CENTRAL_NERVOUS_SYSTEM

Outgoing (11)

Target	Relation	Type	Str
Hepatocellular Carcinoma	modulates	disease	0.95
Neuromyelitis Optica Spectrum Disorder	involved_in	disease	0.90
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.90
Glioblastoma Multiforme	modulates	disease	0.85
Self-Repair Potential	associated_with	phenotype	0.85
Limited Neuroregeneration	associated_with	phenotype	0.85
limited self-repair potential	associated_with	phenotype	0.85
Glioblastoma Multiforme	regulates	disease	0.80
Autophagy	expressed_in	process	0.80
Cellular Senescence	expressed_in	process	0.80
Neuroregeneration	associated_with	process	0.75

Incoming (355)

Source	Relation	Type	Str
MAP6	associated_with	gene	0.50
IDH1	associated_with	gene	0.50
TUMOR	associated_with	disease	0.50
microglia	activates	cell_type	0.50
AQUAPORIN-4	associated_with	gene	0.50
AQP4	expressed_in	gene	0.50
AQUAPORIN-4	expressed_in	gene	0.50
microglia	associated_with	cell_type	0.50
Autoimmune	associated_with	disease	0.50
disease	associated_with	disease	0.50
STROKE	interacts_with	gene	0.50
Autophagy	interacts_with	process	0.50
Endothelial Cell	interacts_with	cell_type	0.50
ENDOTHELIAL	interacts_with	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
PIEZO1	associated_with	gene	0.50
microglia	regulates	cell_type	0.50
PIEZO1	regulates	gene	0.50
Astrocytes	regulates	cell_type	0.50
NEURONS	regulates	concept	0.50
ENDOTHELIAL	regulates	concept	0.50
OLIGODENDROCYTES	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
GLAUCOMA	associated_with	gene	0.50
STROKE	associated_with	gene	0.50
ALZHEIMER	associated_with	gene	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
Glioma	associated_with	disease	0.50
APOE	associated_with	gene	0.50
Neuron	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
MACROPHAGES	associated_with	concept	0.50
ATAXIN-2	associated_with	protein	0.50
Tdp-43	associated_with	pathway	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
aging	associated_with	phenotype	0.50
CX3CR1	expressed_in	gene	0.50
CX3CL1	expressed_in	gene	0.50
TUMOR	interacts_with	disease	0.50
Proteins	interacts_with	protein	0.50
Proteins	expressed_in	protein	0.50
CX43	expressed_in	concept	0.50
inflammation	associated_with	pathway	0.50
AUTISM	associated_with	disease	0.50
NEURODEGENERATIVE DISORDERS	associated_with	concept	0.50
ACTB	interacts_with	gene	0.50
AIF1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

neurodegeneration | 2026-04-07 | 0 hypotheses

How can AQP4 be effectively targeted therapeutically to improve neurological out

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CENTRAL NERVOUS SYSTEM

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

Therapeutics

Neurons — Cell Type Hierarchy

neuroinflammation

GRIA3 Gene

nct07165106

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

NTF4 Protein

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Astrocyte Reactivity Mechanism