Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Brain Atrophy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
Brain_Atrophy["Brain Atrophy"] -->|"mediates"| Cognitive_Decline["Cognitive Decline"]
style Cognitive_Decline fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Brain_Atrophy["Brain Atrophy"] -->|"biomarker for"| Multiple_Sclerosis["Multiple Sclerosis"]
style Multiple_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
p_tau217["p-tau217"] -->|"correlates with"| Brain_Atrophy["Brain Atrophy"]
style p_tau217 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Bd_Tau["Bd-Tau"] -->|"biomarker for"| Brain_Atrophy["Brain Atrophy"]
style Bd_Tau fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"causes"| Brain_Atrophy["Brain Atrophy"]
style Frontotemporal_Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ALPS_Index["ALPS Index"] -->|"correlates with"| Brain_Atrophy["Brain Atrophy"]
style ALPS_Index fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Mab2A7["Mab2A7"] -->|"treats"| Brain_Atrophy["Brain Atrophy"]
style Mab2A7 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
style Brain_Atrophy fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Cognitive Decline | mediates | phenotype | 0.87 |
| Multiple Sclerosis | biomarker_for | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| p-tau217 | correlates_with | biomarker | 0.95 |
| Bd-Tau | biomarker_for | biomarker | 0.92 |
| Frontotemporal Dementia | causes | disease | 0.90 |
| ALPS Index | correlates_with | biomarker | 0.90 |
| P-Tau217 | correlates_with | biomarker | 0.90 |
| Mab2A7 | treats | drug | 0.90 |
| Neurodegeneration | causes | process | 0.90 |
| P2RX7 | contributes_to | gene | 0.90 |
| ATG2A | causes | gene | 0.90 |
| Alps Index | biomarker_for | biomarker | 0.88 |
| Multiple Sclerosis | causes | disease | 0.85 |
| ApoE4 | contributes_to | protein | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||