disease

Multiple Sclerosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Multiple Sclerosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2461Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Multiple Sclerosis is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with AQP4-Antibody-Positive NMOSD, Aging, Als. Connected to 955 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	AQP4, APOE, C1QA, CR1, CX3CL1, CXCR1, STING, MOG
Therapeutic Agents	Immunomodulatory Treatment, Immunosuppressive Treatment, Disease-Modifying Therapies, Monoclonal Antibodies, Chimeric Antigen Receptor T Cell Therapy, Ketogenic Diet
KG Connections	1552 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"therapeutic target"| Complement["Complement"]
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"regulates"| Phagocytosis["Phagocytosis"]
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"associated"| Complement_1["Complement"]
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"therapeutic target"| Endocytosis["Endocytosis"]
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"therapeutic target"| Exocytosis["Exocytosis"]
    CALCOCO2["CALCOCO2"] -->|"associated"| Multiple_Sclerosis["Multiple Sclerosis"]
    HK2["HK2"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    AQP4["AQP4"] -->|"associated"| Multiple_Sclerosis["Multiple Sclerosis"]
    CD19["CD19"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    style Multiple_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (748)

Target	Relation	Type	Str
Neurodegeneration	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Neurodegeneration	regulates	disease	1.00
Inflammation	regulates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Alzheimer	associated_with	disease	1.00
Stroke	associated_with	disease	1.00
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Immune Response	therapeutic_target	pathway	1.00
Central Nervous System	associated_with	cell_type	0.95
Inflammation	causes	disease	0.95
Alzheimer	regulates	disease	0.95
Axonal Loss	causes	process	0.95
Demyelination	associated_with	process	0.95
Axonal Damage	causes	phenotype	0.95
Myelin Loss	causes	phenotype	0.95
Demyelinating Disease	involved_in	process	0.95
Demyelination	causes	phenotype	0.90
Neuroaxonal Injury	causes	phenotype	0.90
Neurodegeneration	causes	process	0.90
Visual System Degeneration	causes	phenotype	0.90
Brain Inflammation	causes	process	0.90
Autoimmune Response	causes	process	0.90
Acute Injury	associated_with	process	0.90
Demyelinating Disease	associated_with	disease	0.90
Oligodendrocyte	causes	cell_type	0.90
Oligodendrocyte	downregulates	cell_type	0.90
Axonal Loss	associated_with	phenotype	0.90
Periventricular T2 Lesion	biomarker_for	biomarker	0.90
Dawson'S Finger	biomarker_for	biomarker	0.90
Brain T1 Hypointensity	biomarker_for	biomarker	0.90
Neuronal Cell Death	causes	phenotype	0.90
Blood-Brain Barrier	causes	process	0.90
Visual Pathway Degeneration	causes	process	0.90
Blood-Brain Barrier	activates	pathway	0.90
Immune Response	regulates	pathway	0.90
Periventricular T2 Lesion	associated_with	phenotype	0.89
Dawson's Finger	associated_with	phenotype	0.86
Neuroinflammation	associated_with	disease	0.85
Demyelination	involved_in	process	0.85
Axonal Degeneration	causes	phenotype	0.85
Brain Atrophy	causes	phenotype	0.85
Gray Matter Lesions	causes	phenotype	0.85

Incoming (1713)

Source	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Als	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
ASTROCYTES	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
CYTOKINES	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
MICROGLIA	activates	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
PARKINSON	associated_with	gene	1.00
INFLAMMATION	causes	gene	1.00
NEURODEGENERATION	causes	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
STROKE	associated_with	gene	1.00
Als	therapeutic_target	disease	1.00
Als	implicated_in	disease	1.00
Als	activates	disease	1.00
Als	causes	disease	1.00
PARKINSON'S DISEASE	activates	gene	1.00
PARKINSON	activates	gene	1.00
Parkinson	activates	disease	1.00
ALZHEIMER	regulates	gene	1.00
Autoimmune	associated_with	disease	0.95
DNA	associated_with	gene	0.95
AKT	activates	gene	0.95
MICROGLIA	regulates	gene	0.95
MICROGLIA	associated_with	gene	0.95
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.95
ALZHEIMER'S DISEASE	regulates	gene	0.95
NEUROINFLAMMATION	regulates	gene	0.95
NEURODEGENERATIVE DISEASES	activates	gene	0.95
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.95
MICROGLIA	therapeutic_target	gene	0.95
CYTOKINES	therapeutic_target	gene	0.95
HUNTINGTON	associated_with	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.505

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Multiple Sclerosis

Understanding Entity Pages

Summary

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

oxidative-stress-comparison

Blood-Brain Barrier Dysfunction in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration

AI and Machine Learning in Neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration