Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about atg2a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG2A |
| Full Name | Autophagy Related 2A |
| Chromosome | 11q13.2 |
| Protein Type | Peripheral Membrane Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 206 kDa |
| UniProt ID | [Q9BSB5](https://www.uniprot.org/uniprot/Q9BSB5) |
| GeneCards | ATG2A |
| Human Protein Atlas | ATG2A |
| Associated Diseases | Neurodegeneration, neurodegeneration |
| Interactions | WIPI4 |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATG2A["ATG2A"]
ATG2A -->|"participates in"| autophagosome_lysosome_fusion["autophagosome-lysosome fusion"]
ATG2A -->|"regulates"| phosphatidylethanolamine["phosphatidylethanolamine"]
ATG2A -->|"activates"| Ms["Ms"]
ATG2A -->|"activates"| Neurodegeneration["Neurodegeneration"]
ATG2A -->|"activates"| Ferroptosis["Ferroptosis"]
ATG2A -->|"activates"| Autophagy["Autophagy"]
ATG2A -->|"activates"| WIPI4["WIPI4"]
E2F4["E2F4"] -->|"regulates"| ATG2A
WIPI4 -->|"interacts"| ATG2A
NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| ATG2A
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| ATG2A
WDR45["WDR45"] -->|"activates"| ATG2A
MITOCHONDRIA["MITOCHONDRIA"] -->|"activates"| ATG2A
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ATG2A| Target | Relation | Type | Str |
|---|---|---|---|
| MITOCHONDRIA | activates | cell_type | 0.50 |
| WIPI4 | activates | gene | 0.50 |
| ENDOPLASMIC RETICULUM | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| E2F4 | regulates | protein | 0.90 |
| WIPI4 | regulates | protein | 0.88 |
| WIPI4 | interacts_with | protein | 0.80 |
| YTHDF1 | associated_with | protein | 0.80 |
| WIPI4 | activates | gene | 0.60 |
| WDR45 | activates | gene | 0.60 |
| WDR45 | causes | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| NEURODEGENERATION | causes | gene | 0.60 |
| FERROPTOSIS | causes | gene | 0.60 |
| AUTOPHAGY | causes | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATG2A | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||