Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CATHEPSINB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CATHEPSINB |
| Full Name | Cathepsin B |
| Protein Family | Cysteine cathepsin family (papain-like) |
| Protein Type | Protease |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various cell types throughout the brain: |
| Molecular Weight | 38 kDa (339 amino acids) |
| Amino Acids | 339 aa |
| UniProt ID | P07846 |
| GeneCards | CATHEPSINB |
| Human Protein Atlas | CATHEPSINB |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CATHEPSINB"]
N1["LRRK2"]
N0 -->|"associated with"| N1
N2["TLR2"]
N2 -->|"expressed in"| N0
N3["MICROGLIA"]
N3 -->|"associated with"| N0
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 gene
class N3 gene| Target | Relation | Type | Str |
|---|---|---|---|
| LRRK2 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CATHEPSINB in their description or question text
No additional research found