protein

CATHEPSINB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSINB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

1Outgoing

2Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	CATHEPSIN-B
Full Name	CTSB
Aliases	CATHEPSINB
Chromosome	8p23.1
Protein Type	Gene
Function	encodes cathepsin B, a lysosomal cysteine protease belonging to the papain family
Molecular Weight	~26 kDa (mature form)
Amino Acids	339 aa
Pathways	Oxidative Stress, Synaptic Plasticity, inflammation
UniProt ID	P07846
NCBI Gene ID	1508
GeneCards	CATHEPSIN-B
Human Protein Atlas	CATHEPSIN-B
Interactions	ALZHEIMER, BDNF, IGF-1, CYTOKINES, FGF21, Insulin
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CATHEPSINB — AlphaFold P07846 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CTSB Gene

gene · 917 words

→

Cathepsin B Protein

protein · 1112 words

→

Pathway Diagram

flowchart TD
    N0["CATHEPSINB"]
    N1["LRRK2"]
    N0 -->|"associated with"| N1
    N2["TLR2"]
    N2 -->|"expressed in"| N0
    N3["MICROGLIA"]
    N3 -->|"associated with"| N0
    N4["neurodegeneration"]
    N0 -->|"implicated in"| N4

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene

Outgoing (1)

Target	Relation	Type	Str
LRRK2	associated_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
TLR2	expressed_in	gene	0.60
MICROGLIA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity