Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CRISPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Central Nervous System | targets | brain_region | 0.95 |
| Epigenetic Modifications | mediates | process | 0.95 |
| Metabolic Reprogramming | promotes | process | 0.90 |
| Mitochondrial Genome | edits | genome | 0.90 |
| Adult Neurons | targets | cell_type | 0.85 |
| Misfolded Protein Aggregates | activates | protein | 0.80 |
| MSH3 | inhibits | gene | 0.80 |
| PMS1 | inhibits | gene | 0.80 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.70 |
| neurons | selectively_eliminates | cell | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 | investigates | analysis | 0.95 |
| Viral Vector | mediates | compound | 0.85 |
| Cell-type-specific essential genes | co_associated_with | gene | 0.30 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | co_associated_with | gene | 0.30 |
| NURR1, PITX3, neuronal identity transcription factors | co_associated_with | gene | 0.30 |
| Disease-causing mutations with integrated reporters | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
gene therapy | 2026-04-11 | 0 hypotheses
drug delivery | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |
| Exploring Parkinson's through the Lens of Genomics and Bioinformatics. [PMID:39929729] | Menon V | Cold Spring Harb Perspect Med | 2026 | 0 |
| A Simple Method for RNA-Seq of Manually Isolated Chromatophores in Oryzias Fishe [PMID:41805030] | Goda M, Miyagi A, Sugiwaka K, Watanabe M | Dev Growth Differ | 2026 | 0 |
| Phosphate starvation induces root cell-type-specific transcriptional responses a [PMID:41952296] | González-García MP, Lanza M, Baca-Gonzál | New Phytol | 2026 | 0 |
| Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associate [PMID:41576950] | ["Ghoochani A", "Heiby J", "Rawat E", "M | Cell | 2026 | 0 |
| Decoding Alzheimer's genetic risk through intercellular communication in the hum [PMID:41707523] | Lish AM, Young-Pearse TL | Current opinion in neurobiolog | 2026 | 0 |
| Neuromodulatory role and therapeutic potential of N 6 -methyladenosine RNA methy [PMID:40618260] | Zhang J, Ma W, Liu R, Li X, Yuan Z, Chen | Neural regeneration research | 2026 | 0 |
| Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Progr [PMID:41676679] | Xie Y, Chang L, Zhong G, Rink JA, Báez-B | bioRxiv : the preprint server | 2026 | 0 |
| Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the [PMID:41743852] | Zhang Y, Guo X, Wang Q, Xiao L, Liu Q, G | Research (Washington, D.C.) | 2026 | 0 |
| Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621] | ["Singh R", "Maity P", "Jaiswal C"] | Neurochemistry international | 2026 | 0 |
| Targeting Non-coding RNAs in Neurodegeneration: Advances in Therapeutic RNA Moda [PMID:41588889] | ["Thakur A", "Chowdhury K", "Kumar A", " | Current Alzheimer research | 2026 | 0 |
| Hereditary Polyneuropathies in the Era of Precision Medicine: Genetic Complexity [PMID:41595476] | ["Chrysostomaki M", "Chatzi D", "Kyriako | Genes | 2026 | 0 |
| Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200] | ["Khanal P", "Balmik A"] | CNS & neurological disorders d | 2026 | 0 |
| Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disea [PMID:39824182] | ["Handsaker R", "Kashin S", "Reed N", "T | Cell | 2025 | 0 |
| Whole mitochondrial genome sequencing in individuals with Leber hereditary optic [PMID:40969215] | Srilekha S, Ambika S, Hemavathy N, Vidhy | Front Neurol | 2025 | 0 |
| Exploring rare mitochondrial DNA in Leber hereditary optic neuropathy. [PMID:41080639] | Cao S, Liu Y, Sun M, Zhang Y, Sun Y et a | Adv Ophthalmol Pract Res | 2025 | 0 |
| Metabolic rewiring prevents neurodegeneration caused by chronic mitochondrial dy [PMID:41151583] | Richhariya S, Shin D, Schlichting M, Ros | Current biology : CB | 2025 | 0 |
| Focused ultrasound widely broadens AAV-delivered Cas9 distribution and activity. [PMID:39893321] | Gumusgoz E, Kasiri S, Youssef I, Verma M | Gene therapy | 2025 | 0 |
| VDAC2 loss elicits tumour destruction and inflammation for cancer therapy. [PMID:40108474] | Yuan S, Sun R, Shi H, Chapman NM, Hu H, | Nature | 2025 | 0 |