Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CELL-TYPE-SPECIFIC ESSENTIAL GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CELL-TYPE-SPECIFIC ESSENTIAL GENES |
Knowledge base pages for this entity
graph TD
CELL_TYPE_SPECIFIC_ESSENTIAL_G["CELL-TYPE-SPECIFIC ESSENTIAL GENES"]
CELL_TYPE_SPECIFIC_ESSENTIAL_G -->|"studied_in"| neurodegeneration["neurodegeneration"]
CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| APOE_regulatory_regions["APOE regulatory regions"]
CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| NURR1["NURR1"]
CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| FOXO3["FOXO3"]
CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| PGC1A["PGC1A"]
DMPK["DMPK"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
PGC1A ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
CREB1["CREB1"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
repeat_containing_transcripts["repeat-containing transcripts"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
synaptic_plasticity_genes["synaptic plasticity genes"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.60 |
| FOXO3 | debate_co_mention | gene | 0.45 |
| LDLR | debate_co_mention | gene | 0.45 |
| PITX3 | debate_co_mention | gene | 0.45 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
| HMGCR, LDLR, APOE regulatory regions | debate_co_mention | gene | 0.45 |
| HTT, DMPK, repeat-containing transcripts | debate_co_mention | gene | 0.45 |
| NURR1, PITX3, neuronal identity transcription factors | debate_co_mention | gene | 0.45 |
| RNA | debate_co_mention | gene | 0.45 |
| APOE regulatory regions | co_discussed | gene | 0.40 |
| NURR1 | co_discussed | gene | 0.40 |
| FOXO3 | co_discussed | gene | 0.40 |
| PGC1A | co_discussed | gene | 0.40 |
| BDNF | co_discussed | gene | 0.40 |
| LDLR | co_discussed | gene | 0.40 |
| HTT | co_discussed | gene | 0.40 |
| SIRT1 | co_discussed | gene | 0.40 |
| APOE | co_discussed | gene | 0.40 |
| repeat-containing transcripts | co_discussed | gene | 0.40 |
| PITX3 | co_discussed | gene | 0.40 |
| DMPK | co_discussed | gene | 0.40 |
| synaptic plasticity genes | co_discussed | gene | 0.40 |
| CREB1 | co_discussed | gene | 0.40 |
| HMGCR | co_discussed | gene | 0.40 |
| mitochondrial biogenesis genes | co_discussed | gene | 0.40 |
| neuronal identity transcription factors | co_discussed | gene | 0.40 |
| Disease-causing mutations with integrated reporters | co_discussed | gene | 0.40 |
| neurodegeneration | implicated_in | disease | 0.40 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | co_associated_with | gene | 0.40 |
| NURR1, PITX3, neuronal identity transcription factors | co_associated_with | gene | 0.40 |
| Disease-causing mutations with integrated reporters | co_associated_with | gene | 0.40 |
| CRISPR | co_associated_with | gene | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-63b7bacd | targets_gene | hypothesis | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||