gene

CTSZ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections
0Hypotheses
0Analyses
11Outgoing
5Incoming

Summary

Page for CTSZ Gene - Cathepsin Z

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🧬 Gene Info
Gene SymbolCTSZ
Full NameCathepsin Z
AliasesPage for CTSZ Gene
Chromosome20q13.12
Protein TypeProtease
Function, also known as Cathepsin X, is a unique lysosomal cysteine protease that possesses both endopeptidase and carboxypeptidase activities[@bhling2004]
Primary ExpressionAD brain and localizes to amyloid plaques[@wang2012] 2
PathwaysAutophagy, Immune Response, Mitophagy, lysosomal function
UniProt ID[O60840](https://www.uniprot.org/uniprot/O60840)
Ensembl IDENSG00000021574
OMIM602088
GeneCardsCTSZ
Human Protein AtlasCTSZ
Lysosomal Protein DegradationCentral role in cellular protein turnover
Immune RegulationModulates T-cell function and macrophage activity
Associated Diseasesneurodegeneration
InteractionsAMYLOID, AUTOPHAGY, , Amyloid Beta, CATHEPSINS, TAU
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

CTSZ Gene - Cathepsin Z

gene · 652 words

TREM2-APOE Axis in Neurodegeneration

mechanism · 1888 words

Cathepsin Z Protein

protein · 692 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["CTSZ"]
    N1["lysosomal function"]
    N0 -->|"regulates"| N1
    N2["Urolithin A"]
    N2 -->|"regulates"| N0
    N3["Alzheimer"]
    N0 -->|"activates"| N3
    N4["Als"]
    N0 -->|"activates"| N4
    N5["AMYLOID"]
    N0 -->|"activates"| N5
    N6["AUTOPHAGY"]
    N0 -->|"activates"| N6
    N7["Autophagy"]
    N0 -->|"activates"| N7
    N8["Mitophagy"]
    N0 -->|"activates"| N8
    N9["Immune Response"]
    N0 -->|"activates"| N9
    N10["Abeta"]
    N0 -->|"activates"| N10
    N11["Amyloid Beta"]
    N0 -->|"activates"| N11
    N12["Cathepsin"]
    N0 -->|"regulates"| N12
    N13["ALZHEIMER"]
    N13 -->|"activates"| N0
    N14["CATHEPSINS"]
    N14 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 pathway
    class N9 pathway
    class N10 protein
    class N11 protein
    class N12 protein
    class N13 gene
    class N14 gene

Outgoing (11)

TargetRelationTypeStr
lysosomal functionregulatesprocess0.70
Alzheimeractivatesdisease0.65
Alsactivatesdisease0.65
AMYLOIDactivatesgene0.60
AUTOPHAGYactivatesgene0.60

Incoming (5)

SourceRelationTypeStr
Urolithin Aregulatesdrug0.70
CATHEPSINSactivatesgene0.60
TAUactivatesgene0.60
ALZHEIMERactivatesgene0.60
MITOPHAGYactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found