Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CTSZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CTSZ |
| Full Name | Cathepsin Z |
| Aliases | Page for CTSZ Gene |
| Chromosome | 20q13.12 |
| Protein Type | Protease |
| Function | , also known as Cathepsin X, is a unique lysosomal cysteine protease that possesses both endopeptidase and carboxypeptidase activities[@bhling2004] |
| Primary Expression | AD brain and localizes to amyloid plaques[@wang2012] 2 |
| Pathways | Autophagy, Immune Response, Mitophagy, lysosomal function |
| UniProt ID | [O60840](https://www.uniprot.org/uniprot/O60840) |
| Ensembl ID | ENSG00000021574 |
| OMIM | 602088 |
| GeneCards | CTSZ |
| Human Protein Atlas | CTSZ |
| Lysosomal Protein Degradation | Central role in cellular protein turnover |
| Immune Regulation | Modulates T-cell function and macrophage activity |
| Associated Diseases | neurodegeneration |
| Interactions | AMYLOID, AUTOPHAGY, Aβ, Amyloid Beta, CATHEPSINS, TAU |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CTSZ"]
N1["lysosomal function"]
N0 -->|"regulates"| N1
N2["Urolithin A"]
N2 -->|"regulates"| N0
N3["Alzheimer"]
N0 -->|"activates"| N3
N4["Als"]
N0 -->|"activates"| N4
N5["AMYLOID"]
N0 -->|"activates"| N5
N6["AUTOPHAGY"]
N0 -->|"activates"| N6
N7["Autophagy"]
N0 -->|"activates"| N7
N8["Mitophagy"]
N0 -->|"activates"| N8
N9["Immune Response"]
N0 -->|"activates"| N9
N10["Abeta"]
N0 -->|"activates"| N10
N11["Amyloid Beta"]
N0 -->|"activates"| N11
N12["Cathepsin"]
N0 -->|"regulates"| N12
N13["ALZHEIMER"]
N13 -->|"activates"| N0
N14["CATHEPSINS"]
N14 -->|"activates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N3 disease
class N4 disease
class N5 gene
class N6 gene
class N7 pathway
class N8 pathway
class N9 pathway
class N10 protein
class N11 protein
class N12 protein
class N13 gene
class N14 gene| Target | Relation | Type | Str |
|---|---|---|---|
| lysosomal function | regulates | process | 0.70 |
| Alzheimer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| AMYLOID | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Aβ | activates | protein | 0.60 |
| Amyloid Beta | activates | protein | 0.60 |
| Cathepsin | regulates | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Urolithin A | regulates | drug | 0.70 |
| CATHEPSINS | activates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||