concept

CATHEPSIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

169Connections

9Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CATHEPSIN

Pathway Diagram

graph TD
    CATHEPSIN["CATHEPSIN"]
    style CATHEPSIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CATHEPSIN -->|"interacts"| Dementia["Dementia"]
    CATHEPSIN -->|"interacts"| Alzheimer["Alzheimer"]
    CATHEPSIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CATHEPSIN -->|"interacts"| Parkinson["Parkinson"]
    CATHEPSIN -->|"interacts"| Als["Als"]
    CATHEPSIN -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CATHEPSIN -->|"regulates"| Ischemia["Ischemia"]
    DISC1([DISC1]) -->|"interacts"| CATHEPSIN
    GBA([GBA]) -->|"interacts"| CATHEPSIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| CATHEPSIN
    ROS([ROS]) -->|"interacts"| CATHEPSIN
    ALS([ALS]) -->|"interacts"| CATHEPSIN
    PINK1([PINK1]) -->|"interacts"| CATHEPSIN
    CTSD([CTSD]) -->|"interacts"| CATHEPSIN
    G3BP1([G3BP1]) -->|"interacts"| CATHEPSIN
    BCL2L13([BCL2L13]) -->|"interacts"| CATHEPSIN
    RB1([RB1]) -->|"interacts"| CATHEPSIN

Outgoing (50)

Target	Relation	Type	Str
Neurodegeneration	associated_with	disease	0.60
Ischemia	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Ischemia	regulates	disease	0.60
Aging	activates	disease	0.60
Diabetes	causes	disease	0.60
Als	regulates	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Aging	regulates	disease	0.60
Diabetes	activates	disease	0.60
Alzheimer	activates	disease	0.60
Dementia	interacts_with	disease	0.60
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Neurodegeneration	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Als	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Ischemia	activates	disease	0.60
Alzheimer	associated_with	disease	0.60
Als	activates	disease	0.60
Neuroinflammation	interacts_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Autophagy	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Complement System	activates	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Cell Cycle	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Lipid Metabolism	interacts_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Autophagy	activates	pathway	0.55
Mitophagy	activates	pathway	0.55
Immune Response	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Wnt	regulates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Synaptic Plasticity	activates	pathway	0.55
Mtor	regulates	pathway	0.55
Lysosomal Degradation	activates	pathway	0.55
Inflammasome	activates	pathway	0.55
Autophagy	regulates	pathway	0.55
Lipid Metabolism	activates	pathway	0.55

Incoming (119)

Source	Relation	Type	Str
PPARG	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
SREBF1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
NADH	regulates	gene	0.60
ACTB	regulates	gene	0.60
RAS	regulates	gene	0.60
CPT1A	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
MTOR	regulates	gene	0.60
LYSOSOME	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
TUBULIN	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DMSO	associated_with	gene	0.60
JUN	activates	gene	0.60
ACTB	associated_with	gene	0.60
SYT1	associated_with	gene	0.60
MAP2	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
IL6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
PRDX6	interacts_with	gene	0.60
CATHEPSINS	associated_with	gene	0.60
CD44	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
LAMP2A	associated_with	gene	0.60

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Cathepsin-Dependent Tau Clearance	0.767	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotecti	0.644	neurodegeneration	Why does autophagy inhibition improve ne
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak
Limited Calcium Release Without Sufficient Cathepsin Efflux	0.580	neurodegeneration	How does controlled lysosomal membrane p

Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak
Cathepsin D Replacement to Overcome Lysosomal Protease Defic	0.434	proteomics	Quantitative proteomics of the aging syn
Cathepsin-Dependent Processing of Pro-Drug Enzymes	0.400	neurodegeneration	How does controlled lysosomal membrane p
Cathepsin D Enhancement for Tau Degradation	0.000	-	Tau propagation mechanisms and therapeut

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Tau, neurodegeneration and Alzheimer's disease. [PMID:21214513]	Unknown	Curr Alzheimer Res	2010
TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124]	Unknown	Prog Brain Res	2008

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CATHEPSIN in their description or question text

Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin

Score: 0.570 · neuroscience · 2026-04-22

## Mechanistic Overview Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin release in AD s

Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency

Score: 0.434 · proteomics · 2026-04-25

Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency

Cathepsin-Dependent Processing of Pro-Drug Enzymes

Score: 0.400 · neurodegeneration · 2026-04-21

## Mechanistic Overview Cathepsin-Dependent Processing of Pro-Drug Enzymes starts from the claim that modulating CTSD, U

Cathepsin D Enhancement for Tau Degradation

Score: 0.000 · unknown disease · 2026-04-28

Recombinant pro-cathepsin D enhances pathological protein degradation in lysosomes. Targeted delivery of stabilized cath