concept

CATHEPSINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

1Analyses

44Outgoing

31Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	Cathepsin S Protein
Summary	Page for Cathepsin S Protein
Key Genes/Proteins	CD44, SERPINA3, GFAP, LRP1, TNF, NFE2L2
Related Diseases	Alzheimer, Neuroinflammation, Inflammation, ALS, Als

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CATHEPSINS["CATHEPSINS"]
    CATHEPSINS -->|"interacts"| Alzheimer["Alzheimer"]
    CATHEPSINS -->|"interacts"| Neuroinflammation["Neuroinflammation"]
    CATHEPSINS -->|"interacts"| Inflammation["Inflammation"]
    CATHEPSINS -->|"activates"| ALS["ALS"]
    CATHEPSINS -->|"activates"| Als["Als"]
    CATHEPSINS -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    CATHEPSINS -->|"interacts"| Mapk["Mapk"]
    NOS1["NOS1"] -->|"interacts"| CATHEPSINS
    IL6["IL6"] -->|"interacts"| CATHEPSINS
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"interacts"| CATHEPSINS
    APOE["APOE"] -->|"interacts"| CATHEPSINS
    SERPINA3["SERPINA3"] -->|"interacts"| CATHEPSINS
    PRDX6["PRDX6"] -->|"interacts"| CATHEPSINS
    MT1A["MT1A"] -->|"interacts"| CATHEPSINS
    CD44["CD44"] -->|"interacts"| CATHEPSINS

Outgoing (44)

Target	Relation	Type	Str
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
CD44	interacts_with	gene	0.60
SERPINA3	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
CRYAB	associated_with	gene	0.60
NLRP3	activates	gene	0.60
TAU	activates	gene	0.60
CTSZ	activates	gene	0.60
APOE	interacts_with	gene	0.60
Oxidative Stress	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Sod1	interacts_with	pathway	0.60
Lipid Metabolism	interacts_with	pathway	0.60
Apoptosis	activates	pathway	0.60
Amyloid	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
ASTROCYTE	interacts_with	gene	0.60
Astrocyte	interacts_with	cell_type	0.60
Cathepsin	associated_with	protein	0.60
AMYLOID	activates	gene	0.60
IL-1	activates	gene	0.60
T Cell	activates	cell_type	0.60
Aβ	activates	protein	0.60
Interleukin	activates	protein	0.60
Caspase	activates	protein	0.60
Amyloid Beta	activates	protein	0.60
Cathepsin	activates	protein	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Il-1	activates	protein	0.60
Astrocyte	expressed_in	cell_type	0.55
T Cell	expressed_in	cell_type	0.55

Incoming (31)

Source	Relation	Type	Str
NOS1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
SERPINA3	interacts_with	gene	0.60
PRDX6	interacts_with	gene	0.60
MT1A	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
MMP1	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
CRYAB	associated_with	gene	0.60
LRP1	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
AND	associated_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HSPB1	associated_with	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
IL-1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CATHEPSINS

Understanding Entity Pages

Wiki Pages (21)

Cathepsin S Protein

cbs-psp-daily-action-plan

Novel Therapy Index

Frontotemporal Dementia (FTD) Mechanistic Pathway

Multiple System Atrophy

Autophagy Mechanisms

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Niemann-Pick Disease Type C (NPC)

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

Beta-Secretase (BACE1) Protein

GBA1→GCase→Lysosome→PD Causal Chain

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Genistein for Mild Cognitive Impairment (NCT07385937)

rapamycin-tauopathy

Frontotemporal Dementia

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

DLK2 — Delta-Like Non-Canonical Notch Ligand 2