Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UROLITHIN A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | UROLITHIN A |
Knowledge base pages for this entity
graph TD
UROLITHIN_A["UROLITHIN A"]
UROLITHIN_A -->|"inhibits"| Amyloidogenesis["Amyloidogenesis"]
UROLITHIN_A -->|"activates"| TFEB["TFEB"]
UROLITHIN_A -->|"inhibits"| RANKL["RANKL"]
UROLITHIN_A -->|"inhibits"| osteoclastogenesis["osteoclastogenesis"]
UROLITHIN_A -->|"inhibits"| IL6["IL6"]
UROLITHIN_A -->|"inhibits"| TNF["TNF"]
UROLITHIN_A -->|"inhibits"| NF_kB_pathway["NF-kB pathway"]
UROLITHIN_A -->|"inhibits"| NLRP3["NLRP3"]
Ellagic_Acid["Ellagic Acid"] -->|"product_of"| UROLITHIN_A| Target | Relation | Type | Str |
|---|---|---|---|
| Amyloidogenesis | inhibits | process | 0.95 |
| TFEB | activates | protein | 0.95 |
| Amyloidogenesis | suppresses | process | 0.95 |
| Mitophagy | associated_with | process | 0.95 |
| RANKL | inhibits | protein | 0.90 |
| osteoclastogenesis | inhibits | phenotype | 0.90 |
| IL6 | inhibits | protein | 0.90 |
| TNF | inhibits | protein | 0.90 |
| NF-kB pathway | inhibits | pathway | 0.90 |
| NLRP3 | inhibits | protein | 0.90 |
| Cognition | associated_with | phenotype | 0.90 |
| Lysosomal Function | associated_with | process | 0.90 |
| Lysosomal function | associated_with | biological_process | 0.90 |
| pyroptosis | inhibits | phenotype | 0.90 |
| Alzheimer's Disease | treats | disease | 0.90 |
| IL-6 | inhibits | protein | 0.90 |
| TNF-α | inhibits | protein | 0.90 |
| mitophagy | activates | process | 0.88 |
| TGM2 | modulates | protein | 0.85 |
| Mitochondrial ROS Accumulation | inhibits | process | 0.80 |
| Calcium Homeostasis | modulates | process | 0.80 |
| Neuroprotection | mediates | process | 0.80 |
| MITOPHAGY | promotes | process | 0.80 |
| Oxidative Stress | protects_against | process | 0.80 |
| CTSZ | regulates | protein | 0.70 |
| amyloid beta | inhibits | protein | 0.70 |
| tau | inhibits | protein | 0.70 |
| lysosomal function | restores | process | 0.70 |
| mitophagy | activates | process | 0.70 |
| Alzheimer's disease | treats | disease | 0.70 |
| MIR-34A | inhibits | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Ellagic Acid | product_of | compound | 0.95 |
| Ellagitannins | associated_with | compound | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||