Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MITOPHAGY is an entity related to neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 2027 entities in the SciDEX knowledge graph.
| Name | MITOPHAGY |
| Summary | Comprehensive circuit analysis of PSP including brainstem oculomotor circuits, basal ganglia circuits, and therapeutic approaches |
| Key Genes/Proteins | MITOCHONDRIAL DYSFUNCTION, PINK1, AKT, INFLAMMATION, SQSTM1, AUTOPHAGY |
| Related Diseases | Neuroinflammation, Inflammation, Fibrosis |
| Related Pathways | Mitophagy, Autophagy, Apoptosis |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
graph TD
MITOPHAGY["MITOPHAGY"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"associated"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"protects against"| ALZHEIMER_S_DISEASE_1["ALZHEIMER'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
MITOPHAGY["MITOPHAGY"] -->|"associated"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
MITOPHAGY["MITOPHAGY"] -->|"regulates"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE_DISEASES"]
PARKIN["PARKIN"] -->|"regulates"| MITOPHAGY["MITOPHAGY"]
PINK1["PINK1"] -->|"participates in"| MITOPHAGY["MITOPHAGY"]
PRKN["PRKN"] -->|"participates in"| MITOPHAGY["MITOPHAGY"]
PINK1_2["PINK1"] -->|"regulates"| MITOPHAGY["MITOPHAGY"]
style MITOPHAGY fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MITOCHONDRIA | regulates | cell_type | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| AKT | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| Fibrosis | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Mitophagy | associated_with | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Ischemia | regulates | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| CANCER | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Mitophagy | inhibits | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Neurodegeneration | inhibits | disease | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Mitophagy | therapeutic_target | pathway | 1.00 |
| PARKIN | activates | gene | 1.00 |
| Parkinson | activates | disease | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| P62 | associated_with | gene | 1.00 |
| Cardiac | regulates | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | activates | protein | 1.00 |
| PARKIN | regulates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| PINK1 | inhibits | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| PINK1 | expressed_in | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 0.98 |
| PINK1 | mediates | entity | 0.95 |
| PARKIN | mediates | entity | 0.95 |
| AUTOPHAGY | involved_in | process | 0.95 |
| SQSTM1 | substrate_of | entity | 0.90 |
| PRKN | mediates | gene | 0.90 |
| MITOCHONDRIA | involved_in | cell_type | 0.90 |
| BNIP3L/NIX | degrades | gene | 0.90 |
| SIRT1 | enhances | gene | 0.90 |
| polystyrene nanoplastic | activates | compound | 0.90 |
| OPTINEURIN | mediates | protein | 0.90 |
| CLU | controls | gene | 0.90 |
| CKLF | triggers | gene | 0.90 |
| BOK | promotes | gene | 0.90 |
| PINK1/Parkin signaling pathway | mediates | pathway | 0.90 |
| PI3K/Akt-Nrf2 signaling pathway | synergistically_mediates | pathway | 0.90 |
| MIF | inhibits | protein | 0.90 |
| PINK1 | associated_with | gene | 0.90 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.90 |
| ROS | regulates | gene | 0.90 |
| TFEB | activates | gene | 0.90 |
| NEURON | regulates | cell_type | 0.86 |
| BNIP3 | mediates | gene | 0.85 |
| FUNDC1 | mediates | gene | 0.85 |
| AMPK | activates | gene | 0.82 |
| APP | associated_with | gene | 0.82 |
| AUTOPHAGY | inhibits | gene | 0.82 |
| AMPK | promotes | protein | 0.80 |
| PINK1/Parkin | mediates | pathway | 0.80 |
| PI3K/Akt-Nrf2 | mediates | pathway | 0.80 |
| OMA1 | promotes | gene | 0.80 |
| LKB1 | regulates | gene | 0.80 |
| PINK1-PARKIN | mediates | pathway | 0.80 |
| FGF21 | promotes | protein | 0.80 |
| MIF | suppresses | protein | 0.80 |
| sepsis-associated acute kidney injury | suppresses | disease | 0.80 |
| CARM1 | drives | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NLRP3/Mitophagy Coupling Modulation | 0.522 | Neuroinflammation | Immune atlas neuroinflammation analysis |
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.509 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi | 0.455 | neurodegeneration | Why does PRKN-mediated mitophagy, typica |
| PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor | 0.418 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189] | ["Cho S", "Jo E", "Jang H"] | Scientific reports | 2026 | 0 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Fang Y, Deng M, Huang K, Song H, Chu Y, | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832] | ["Tang M", "Outissint I", "Chen Y", "Gon | Journal of cellular biochemist | 2025 | 0 |
| H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alz [PMID:39862777] | Wang H, Xia H, Bai J, Wang Z, Wang Y et | J Hazard Mater | 2025 | 0 |
| The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic [PMID:40826276] | Weber ANR, McManus RM, Hornung V, Geyer | Nat Immunol | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |