Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DIPEPTIDE REPEAT PROTEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DIPEPTIDE REPEAT PROTEINS |
| Key Genes/Proteins | FUS |
| Related Diseases | Amyotrophic Lateral Sclerosis, C9orf72-ALS/FTD |
| Related Pathways | Repeat-associated non-AUG translation |
Knowledge base pages for this entity
graph TD
DIPEPTIDE_REPEAT_PROTEINS["DIPEPTIDE REPEAT PROTEINS"]
DIPEPTIDE_REPEAT_PROTEINS -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
DIPEPTIDE_REPEAT_PROTEINS -.biomarker for.-> Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
DIPEPTIDE_REPEAT_PROTEINS -->|"causes"| Toxic_Gain_Of_Function["Toxic Gain Of Function"]
DIPEPTIDE_REPEAT_PROTEINS -->|"expressed in"| Motor_Cortex["Motor Cortex"]
DIPEPTIDE_REPEAT_PROTEINS -->|"expressed in"| Spinal_Cord["Spinal Cord"]
GSK2606414["GSK2606414"] -->|"downregulates"| DIPEPTIDE_REPEAT_PROTEINS
Aberrant_Splicing["Aberrant Splicing"] -->|"involved_in"| DIPEPTIDE_REPEAT_PROTEINS
Antisense_Oligonucleotides["Antisense Oligonucleotides"] -->|"downregulates"| DIPEPTIDE_REPEAT_PROTEINS
C9ORF72["C9ORF72"] -->|"produces"| DIPEPTIDE_REPEAT_PROTEINS
GGGGCC_repeat_RNA["GGGGCC repeat RNA"] -->|"activates"| DIPEPTIDE_REPEAT_PROTEINS| Target | Relation | Type | Str |
|---|---|---|---|
| Amyotrophic Lateral Sclerosis | biomarker_for | disease | 0.90 |
| Neurodegeneration | contributes_to | process | 0.85 |
| C9orf72-ALS/FTD | contributes_to | disease | 0.85 |
| FUS | interacts_with | protein | 0.85 |
| Abnormal Phase Transition | causes | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Repeat-associated non-AUG translation | produces | mechanism | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||