gene

DLST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

Summary

DLST encodes the E2 component of alpha-ketoglutarate dehydrogenase complex, a key TCA cycle enzyme. It plays critical roles in mitochondrial metabolism, NADH production, and is implicated in Parkinson's disease through GWAS and mitochondrial dysfunction.

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🧬 Gene Info

Gene Symbol	DLST
Full Name	Dihydrolipoamide Succinyltransferase
Chromosome	14q24.3
Protein Type	Enzyme
Function	E1 component (OGDH): α-ketoglutarate dehydrogenase — decarboxylates α-ketoglutarate
Molecular Weight	48 kDa
UniProt ID	[P36957](https://www.uniprot.org/uniprot/P36957)
Ensembl ID	ENSG00000135842
GeneCards	DLST
Human Protein Atlas	DLST
Subunit structure	Forms a 24-mer core in the α-KGDH complex
Molecular weight	~48 kDa per subunit
Catalytic function	Transfers the acyl group from the lipoyl moiety to CoA
Lipoate binding	Contains lipoyl-lysine domains that are essential for function
Associated Diseases	neurodegeneration
Interactions	CANCER
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DLST — Dihydrolipoamide Succinyltransferase

gene · 2615 words

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Pathway Diagram

flowchart TD
    DLST(["DLST"])
    Ovarian_Cancer["Ovarian Cancer"]
    Cancer["Cancer"]
    Senescence["Senescence"]
    CANCER(["CANCER"])
    GENES(["GENES"])
    Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    neurodegeneration["neurodegeneration"]

    DLST -->|"activates"| Ovarian_Cancer
    DLST -->|"activates"| Cancer
    DLST -->|"activates"| Senescence
    DLST -->|"activates"| CANCER
    DLST -->|"causes"| GENES
    DLST -->|"causes"| Oxidative_Phosphorylation
    DLST -->|"implicated in"| neurodegeneration

    style DLST fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (6)

Target	Relation	Type	Str
Ovarian Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Senescence	activates	disease	0.65
CANCER	activates	gene	0.60
GENES	causes	gene	0.60
Oxidative Phosphorylation	causes	pathway	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLST in their description or question text

No additional research found