Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNA damage repair: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Ytx-7739 | inhibits | drug | 0.90 |
| PRMT inhibitor | downregulates | drug | 0.90 |
| PARP1 | involved_in | protein | 0.85 |
| P53 | regulates | gene | 0.85 |
| PRMT1 | regulates | entity | 0.80 |
| PRMT5 | regulates | entity | 0.80 |
| PRMT4 | regulates | gene | 0.80 |
| TP53 | regulates | gene | 0.80 |
| protein arginine methylation | modulates | process | 0.75 |
| Autophagy | associated_with | process | 0.75 |
| LRRK2 | disrupts | gene | 0.60 |
| SIRT6 | participates_in | gene | 0.38 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi | 0.681 | neurodegeneration | CRISPR-based therapeutic approaches for |
| SIRT6-NAD+ Axis Enhancement Therapy | 0.667 | neurodegeneration | Epigenetic clocks and biological aging i |
| Oligodendrocyte DNA Repair Enhancement Therapy | 0.665 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su | 0.661 | neurodegeneration | What upstream mechanisms trigger p53 act |
| Oligodendrocyte DNA Repair Enhancement | 0.550 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Sirtuin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Sirtuin Pathway Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] | Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X | Theranostics | 2023 | 1 |
| Assessing the Status of Mandatory Tuberculosis Case Notification among Private P [PMID:35068738] | Duggal K, Elsy M, Majella MG, Akkilagunt | Indian J Community Med | 2021 | 1 |
| Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic [PMID:33888596] | Yoshino M, Yoshino J, Kayser BD, Patti G | Science | 2021 | 1 |
| Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. [PMID:33377090] | Dowling P, Gargan S, Zweyer M, Henry M, | STAR Protoc | 2020 | 1 |
| Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity [PMID:30193097] | Latorre-Muro P, Baeza J, Armstrong EA, H | Mol Cell | 2018 | 1 |
| The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcin [PMID:28329682] | Nargund AM, Pham CG, Dong Y, Wang PI, Os | Cell Rep | 2017 | 1 |
| Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PMID:26686024] | Wiley CD, Velarde MC, Lecot P, Liu S, Sa | Cell Metab | 2016 | 1 |
| SIRT6 inhibits intermittent hypoxia-induced lung injury by stabilizing NRF2. [PMID:41478020] | Qin R, Liu Z, Li R, Li Y, Yang Y et al. | Tissue Cell | 2026 | 0 |
| Inflammation-targeted single-atom nanozymes drive microglial depolarization and [PMID:41624511] | Liu B, Xiang C, Zhang X, Guo W, Wu H et | Mater Today Bio | 2026 | 0 |
| Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544] | Köcher S, Elsesy ME, Moustafa A, Mohamma | J Clin Invest | 2026 | 0 |
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |
| Bupleurum chinense ameliorates metabolic-associated fatty liver disease by modul [PMID:41666508] | Liu S, Chen P, Li Y, Pan Z, Zhang C et a | Phytomedicine | 2026 | 0 |
| Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453] | Shao B, Yin H, Zhang S, He S, Lu H et al | Cancer Genet | 2026 | 0 |
| Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852] | Liu J, Gonzalez-Hunt CP, Richbourg T, Ba | bioRxiv : the preprint server | 2026 | 0 |
| PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038] | Dumoulin I, Lee BJ, Zhang C, Lin X, Wang | bioRxiv | 2026 | 0 |
| Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005] | Wan Z, Li X, Wang Y, Miao S, Chen Z et a | Insects | 2026 | 0 |
| Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367] | Dauben H, Mihaljević M, Kolvenbach A, Pa | Nat Commun | 2026 | 0 |
| SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glut [PMID:41136182] | Zhang M, Chen C, Zhang H, Long T, Wang T | Gut | 2025 | 0 |
| SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Tho [PMID:39633576] | Leng S, Li H, Zhang P, Dang Z, Shao B, X | Arteriosclerosis, thrombosis, | 2025 | 0 |
| On the interface of aging, cancer, and neurodegeneration with SIRT6 and L1 retro [PMID:39251041] | Nahálková J | Ageing research reviews | 2024 | 0 |
Multi-agent debates referencing this entity