PRMT5

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRMT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PRMT5 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, activates. Associated with AD, ALS, ARM. Connected to 76 entities in the SciDEX knowledge graph.

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graph TD
    PRMT5["<b>PRMT5</b>"]
    Cancer{"Cancer"}
    PRMT5 -->|"therapeutic target"| Cancer
    Cardiovascular{"Cardiovascular"}
    PRMT5 -->|"therapeutic target"| Cardiovascular
    Ms{"Ms"}
    PRMT5 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    PRMT5 -->|"therapeutic target"| Tumor
    Als{"Als"}
    PRMT5 -->|"therapeutic target"| Als
    Carcinoma{"Carcinoma"}
    PRMT5 -->|"inhibits"| Carcinoma
    PRMT5 -->|"inhibits"| Ms
    PRMT5 -->|"inhibits"| Cancer
    PRMT5 -->|"inhibits"| Tumor
    PRMT5 -->|"regulates"| Cancer
    PRMT5 -->|"regulates"| Cardiovascular
    ALS{"ALS"}
    PRMT5 -->|"inhibits"| ALS
    PRMT1["PRMT1"]
    PRMT1 -->|"inhibits"| PRMT5
    PRMT1 -->|"therapeutic target"| PRMT5
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"inhibits"| PRMT5
    GPX4["GPX4"]
    GPX4 -->|"inhibits"| PRMT5
    CANCER["CANCER"]
    CANCER -->|"inhibits"| PRMT5
    DNA["DNA"]
    DNA -->|"inhibits"| PRMT5
    AND["AND"]
    AND -->|"inhibits"| PRMT5
    DNA -->|"regulates"| PRMT5
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"inhibits"| PRMT5
    PRMT1 -->|"regulates"| PRMT5
    style PRMT5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0