gene

NEK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

0Hypotheses

1Analyses

50Outgoing

46Incoming

Summary

NEK1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 28 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NEK1
Full Name	NIMA Related Kinase 1
Chromosome	4q33
Protein Type	Serine/Threonine Kinase
Function	NEK1 is a multifunctional kinase with roles spanning several critical cellular processes.
Primary Expression	Motor cortex, Spinal cord, Widespread
Molecular Weight	145 kDa
UniProt ID	Q96PY6
NCBI Gene ID	4750
Ensembl ID	ENSG00000137601
OMIM	604588
GeneCards	NEK1
Human Protein Atlas	NEK1
Symbol [@white2007] NEK1 [@fang2015] [@rifai2025] [@sagu2024] Full Name [@helal2025] NIMA Related Kinase 1 Chromosome	4q33
Associated Diseases	ALS, APOPTOSIS, Amyotrophic Lateral Sclerosis, Ms
Interactions	Stat3, TBK1, RIPK1, App, STAT3, HDAC8
KG Connections	108 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEK1 — AlphaFold Q96PY6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NEK1["<b>NEK1</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    NEK1 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    NEK1 -->|"therapeutic target"| Ms
    Als{"Als"}
    NEK1 -->|"associated with"| Als
    SOD1["SOD1"]
    NEK1 -->|"therapeutic target"| SOD1
    TBK1["TBK1"]
    NEK1 -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    NEK1 -->|"implicated in"| neurodegeneration
    CHCHD10["CHCHD10"]
    CHCHD10 -->|"associated with"| NEK1
    C21ORF2["C21ORF2"]
    C21ORF2 -->|"associated with"| NEK1
    GENES["GENES"]
    GENES -->|"associated with"| NEK1
    DNA["DNA"]
    DNA -->|"therapeutic target"| NEK1
    SOD1 -->|"therapeutic target"| NEK1
    style NEK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (62)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	causes	disease	0.85
oxidative stress response	participates_in	pathway	0.80
ALS	causes	disease	0.70
HDAC6	causes	gene	0.65
C9orf72	exacerbates	gene	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.65
Ms	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Als	inhibits	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
NEURONS	activates	cell_type	0.65
SOD1	therapeutic_target	gene	0.60
TBK1	associated_with	gene	0.60
VCP	contributes_to	gene	0.60
C21ORF2	contributes_to	gene	0.60
CHCHD10	associated_with	gene	0.60
C21ORF2	associated_with	gene	0.60
Stat3	inhibits	protein	0.60
SETX	causes	gene	0.60
SOD1	causes	gene	0.60
SQSTM1	causes	gene	0.60
TARDBP	causes	gene	0.60
TBK1	causes	gene	0.60
VCP	causes	gene	0.60
OPTN	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TBK1	implicated_in	gene	0.60
TBP	implicated_in	gene	0.60
TBK1	interacts_with	gene	0.60
VCP	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
RIPK1	activates	gene	0.60
RIPK1	protects_against	gene	0.60
RIPK1	inhibits	gene	0.60
neuroinflammation	inhibits	disease	0.60
ALS	contributes_to	gene	0.60
MOTOR NEURONS	implicated_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
ALS	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Dna Repair	therapeutic_target	pathway	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60

Incoming (46)

Source	Relation	Type	Str
ALS	implicated_in	gene	0.70
CHCHD10	associated_with	gene	0.60
C21ORF2	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
TBK1	associated_with	gene	0.60
HDAC6	therapeutic_target	gene	0.60
TUBULIN	causes	gene	0.60
STAT3	inhibits	gene	0.60
HDAC8	activates	gene	0.60
FIG4	causes	gene	0.60
FUS	causes	gene	0.60
CCNF	implicated_in	gene	0.60
CTSF	implicated_in	gene	0.60
DNAJC7	implicated_in	gene	0.60
GLT8D1	implicated_in	gene	0.60
KIF5A	implicated_in	gene	0.60
MFSD8	implicated_in	gene	0.60
FUS	associated_with	gene	0.60
CCNF	interacts_with	gene	0.60
CHCHD10	interacts_with	gene	0.60
HDAC6	inhibits	gene	0.60
DCBLD1	interacts_with	gene	0.60
C21ORF2	interacts_with	gene	0.60
KIF5A	interacts_with	gene	0.60
C21ORF2	activates	gene	0.60
C21ORF2	regulates	gene	0.60
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
MATR3	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AND	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
ALS	contributes_to	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
AND	therapeutic_target	gene	0.60
ALS	interacts_with	gene	0.60
MATR3	interacts_with	gene	0.60
HIF	activates	gene	0.60
ALS	causes	gene	0.60
ALS	regulates	gene	0.60
DNA	causes	gene	0.60
ALS	inhibits	gene	0.60
DNA	activates	gene	0.60
ANGPTL4	interacts_with	gene	0.60
ALS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEK1

Understanding Entity Pages

Summary

Wiki Pages (7)

NEK1 — NIMA Related Kinase 1

MFSD8 — Major Facilitator Superfamily Domain Containing 8

NEK1 Protein

C21orf2 — Chromosome 21 Open Reading Frame 2

GLT8D1 — Glycosyltransferase 8 Domain Containing 1

Proteins

Genes