Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DVL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DVL3 |
| Full Name | Dishevelled Segment Polarity Protein 3 |
| Chromosome | 3q27.1 |
| Function | Wnt signaling: Transduces both canonical and non-canonical Wnt signals |
| Molecular Weight | 82 kDa |
| Amino Acids | 740 aa |
| Pathways | Wnt signaling, wnt, Wnt |
| GeneCards | DVL3 |
| Human Protein Atlas | DVL3 |
| Neuronal migration | DVL3-mediated PCP signaling controls radial migration of cortical neurons during corticogenesis |
| Axon guidance | The DVL3-DAAM1-RHOA axis regulates growth cone dynamics and axonal pathfinding |
| Dendritic arborization | PCP signaling influences dendritic branching and spine morphogenesis |
| Ciliary basal body positioning | DVL3 localizes to the basal body and regulates ciliary placement during neural tube development |
| Radial migration | DVL3 regulates the transition of neurons from the ventricular zone to the cortical plate |
| Multipolar migration | DVL3-mediated PCP signaling controls the morphodynamic changes of migrating neurons |
| Associated Diseases | neurodegeneration |
| Interactions | MEX3A |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DVL3["<b>DVL3</b>"]
Als{"Als"}
DVL3 -->|"expressed in"| Als
Anxiety{"Anxiety"}
DVL3 -->|"expressed in"| Anxiety
Depression{"Depression"}
DVL3 -->|"expressed in"| Depression
Complement(["Complement"])
DVL3 -->|"expressed in"| Complement
neurodegeneration["neurodegeneration"]
DVL3 -->|"implicated in"| neurodegeneration
IL_6["IL-6"]
IL_6 -->|"expressed in"| DVL3
style DVL3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| WNT | regulates | pathway | 0.85 |
| Wnt/β-catenin/c-Myc/SOX2 | activates | pathway | 0.80 |
| EMT | associated_with | biological_process | 0.80 |
| Cancer Stem-Like Cells | associated_with | cell_type | 0.80 |
| Als | expressed_in | disease | 0.65 |
| Anxiety | expressed_in | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Complement | expressed_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||