Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Depression: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Depression is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 993 entities in the SciDEX knowledge graph.
| Prevalence | ~280 million people worldwide |
| Associated Genes | TGM2, MAOB, GABRA1, CHAT, CYP2D6, APOE, HMGCR, OPRM1 |
| Therapeutic Agents | Ginsenoside Rg1, Caffeine, Rapamycin, Peganum Harmala, Serotonin Reuptake Inhibitors, Ketamine |
| KG Connections | 1722 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
flowchart TD
DEPRESSION(["DEPRESSION"])
Alzheimer["Alzheimer"]
Depression["Depression"]
Anxiety["Anxiety"]
Inflammation["Inflammation"]
Parkinson["Parkinson"]
Als["Als"]
DEPRESSION -->|"associated with"| Alzheimer
DEPRESSION -->|"associated with"| Depression
DEPRESSION -->|"associated with"| Anxiety
DEPRESSION -.->|"inhibits"| Depression
DEPRESSION -->|"regulates"| Depression
DEPRESSION -->|"contributes to"| Depression
DEPRESSION -->|"activates"| Inflammation
DEPRESSION -->|"associated with"| Parkinson
DEPRESSION -->|"activates"| Depression
DEPRESSION -->|"associated with"| Inflammation
DEPRESSION -->|"associated with"| Als
DEPRESSION -->|"interacts with"| Depression
DEPRESSION -->|"therapeutic target"| Als
DEPRESSION -->|"activates"| Als
DEPRESSION -->|"therapeutic target"| Depression
style DEPRESSION fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 1.00 |
| Neurogenesis | activates | pathway | 1.00 |
| Alzheimer's Disease | associated_with | disease | 0.95 |
| Synaptic Plasticity | associated_with | pathway | 0.90 |
| Oxidative Stress | activates | pathway | 0.90 |
| Cortical atrophy | promotes | phenotype | 0.88 |
| Alzheimer's Disease onset | causes | phenotype | 0.87 |
| Synaptic Plasticity | activates | pathway | 0.85 |
| Neurodegeneration | therapeutic_target | disease | 0.85 |
| Obesity | risk_factor_for | disease | 0.85 |
| Perineuronal Nets | associated_with | structure | 0.85 |
| Alzheimer's Disease | risk_factor_for | disease | 0.85 |
| Cognitive Impairment | co_expressed_with | phenotype | 0.80 |
| Serotonin-Dependent Signaling | associated_with | pathway | 0.80 |
| Anxiety-Like Behaviors | associated_with | phenotype | 0.80 |
| Glaucoma | contributes_to | disease | 0.80 |
| Tau pathology | promotes | phenotype | 0.80 |
| Complement | regulates | pathway | 0.80 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.80 |
| Nf-Κb | activates | pathway | 0.80 |
| Mapk | activates | pathway | 0.80 |
| Autophagy | activates | pathway | 0.80 |
| Oxidative Stress | therapeutic_target | pathway | 0.80 |
| Microbiota | activates | pathway | 0.80 |
| Anxiety | associated_with | disease | 0.75 |
| Inflammation | associated_with | disease | 0.75 |
| Neurodegeneration | associated_with | disease | 0.75 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Synaptic Plasticity | regulates | pathway | 0.70 |
| Epigenetic | associated_with | pathway | 0.70 |
| Blood-Brain Barrier | activates | pathway | 0.70 |
| Er Stress | activates | pathway | 0.70 |
| Complement | associated_with | pathway | 0.70 |
| Oxidative Stress | regulates | pathway | 0.70 |
| Ferroptosis | inhibits | pathway | 0.70 |
| Oxidative Stress | associated_with | pathway | 0.70 |
| Pi3K/Akt | therapeutic_target | pathway | 0.70 |
| Blood-Brain Barrier | treats | pathway | 0.70 |
| Microbiota | associated_with | pathway | 0.70 |
| Inflammasome | activates | pathway | 0.70 |
| Synaptic Plasticity | implicated_in | pathway | 0.70 |
| Oxidative Stress | treats | pathway | 0.70 |
| Immune Response | therapeutic_target | pathway | 0.70 |
| Blood-Brain Barrier | implicated_in | pathway | 0.70 |
| Differentiation | implicated_in | pathway | 0.70 |
| Immune Response | activates | pathway | 0.70 |
| Pi3K/Akt | associated_with | pathway | 0.70 |
| Dysbiosis | therapeutic_target | pathway | 0.70 |
| Microbiota | therapeutic_target | pathway | 0.70 |
| Microbiota | biomarker_for | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| BDNF | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| EXERCISE | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| BDNF | regulates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| DEPRESSION | associated_with | gene | 1.00 |
| ANXIETY | associated_with | gene | 1.00 |
| DEPRESSION | inhibits | gene | 1.00 |
| DEPRESSION | regulates | gene | 1.00 |
| DEPRESSION | contributes_to | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| DEPRESSION | activates | gene | 1.00 |
| ASTROCYTE | activates | gene | 1.00 |
| DEPRESSION | interacts_with | gene | 1.00 |
| DEPRESSION | therapeutic_target | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| DEPRESSION | treats | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| TRKB | activates | gene | 0.95 |
| BDNF | associated_with | gene | 0.95 |
| GENES | associated_with | gene | 0.95 |
| AUTOPHAGY | activates | gene | 0.95 |
| MICROGLIA | activates | gene | 0.95 |
| ASTROCYTES | activates | gene | 0.95 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.95 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.95 |
| INFLAMMATION | therapeutic_target | gene | 0.95 |
| DEMENTIA | associated_with | gene | 0.95 |
| CREB | activates | gene | 0.95 |
| NEURODEGENERATION | associated_with | gene | 0.95 |
| NEURODEGENERATION | therapeutic_target | gene | 0.95 |
| PARKINSON | therapeutic_target | gene | 0.95 |
| DEPRESSION | expressed_in | gene | 0.95 |
| DEPRESSION | causes | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||