disease

Anxiety

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Anxiety: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2285Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

Anxiety is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 487 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	TGM2, MAOB, GABRA1, CHAT, CYP2D6, APOE, HMGCR, OPRM1
Therapeutic Agents	Reboxetine
KG Connections	868 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Anxiety["Anxiety"] -->|"activates"| Nf__b["Nf-Kappab"]
    Anxiety["Anxiety"] -->|"activates"| Complement["Complement"]
    Anxiety["Anxiety"] -->|"activates"| Phagocytosis["Phagocytosis"]
    Anxiety["Anxiety"] -->|"therapeutic target"| Epigenetic["Epigenetic"]
    Anxiety["Anxiety"] -->|"therapeutic target"| Complement_1["Complement"]
    Anxiety["Anxiety"] -->|"associated"| Phagocytosis_2["Phagocytosis"]
    C1Q["C1Q"] -->|"activates"| Anxiety["Anxiety"]
    C1QA["C1QA"] -->|"activates"| Anxiety["Anxiety"]
    TGM2["TGM2"] -->|"associated"| Anxiety["Anxiety"]
    MAOB["MAOB"] -->|"associated"| Anxiety["Anxiety"]
    style Anxiety fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1157)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Hippocampal atrophy	promotes	phenotype	0.90
Oxidative Stress	activates	pathway	0.90
Depression	associated_with	disease	0.85
Alzheimer's Disease onset	causes	phenotype	0.84
Alzheimer's Disease	risk_factor_for	disease	0.82
Cognitive Impairment	co_expressed_with	phenotype	0.80
Als	activates	disease	0.75
Nf-Κb	activates	pathway	0.70
Complement	activates	pathway	0.70
Neurogenesis	activates	pathway	0.70
Synaptic Plasticity	activates	pathway	0.70
Proteasome	activates	pathway	0.70
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Phagocytosis	activates	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Complement	therapeutic_target	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
Inflammasome	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
Toll-Like Receptor	activates	pathway	0.60
Circadian Rhythm	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Er Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Immune Response	regulates	pathway	0.60
Er Stress	associated_with	pathway	0.60
Ferroptosis	activates	pathway	0.60
Oxidative Stress	treats	pathway	0.60
Er Stress	treats	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Mapk	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Senescence	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Mapk	treats	pathway	0.60
Calcium Signaling	treats	pathway	0.60
Camp Signaling	treats	pathway	0.60
Epigenetic	inhibits	pathway	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Dysbiosis	associated_with	pathway	0.60
Microbiota	therapeutic_target	pathway	0.60

Incoming (1128)

Source	Relation	Type	Str
DEPRESSION	associated_with	gene	1.00
ANXIETY	associated_with	gene	1.00
ANXIETY	inhibits	gene	1.00
NEURODEGENERATION	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	0.95
ANXIETY	activates	gene	0.95
ASTROCYTE	activates	gene	0.95
Stress	causes	process	0.95
Leukocytes	biomarker_for	biomarker	0.93
Serotonin	regulates	compound	0.90
Paro Robotic Pet	associated_with	entity	0.90
Reboxetine	treats	drug	0.90
GENES	activates	gene	0.85
BDNF	activates	gene	0.85
ASTROCYTES	activates	gene	0.85
NEUROINFLAMMATION	activates	gene	0.85
ALZHEIMER'S DISEASE	activates	gene	0.85
ANXIETY	causes	gene	0.85
DEPRESSION	causes	gene	0.85
ALZHEIMER	activates	gene	0.85
Circadian Dysregulation	causes	process	0.85
Pharmacogenetics	regulates	process	0.85
Microbiota	associated_with	process	0.80
Gut Microbiota Dysbiosis	associated_with	process	0.80
AADC Deficiency	causes	disease	0.80
Depression	associated_with	disease	0.75
BCL-2	activates	gene	0.75
BAX	activates	gene	0.75
AKT	therapeutic_target	gene	0.75
MICROGLIA	activates	gene	0.75
PARKINSON'S DISEASE	associated_with	gene	0.75
CYTOKINES	associated_with	gene	0.75
GUT-BRAIN AXIS	therapeutic_target	gene	0.75
INFLAMMATION	therapeutic_target	gene	0.75
NEUROINFLAMMATION	therapeutic_target	gene	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
INFLAMMATION	activates	gene	0.75
NRF2	activates	gene	0.75
PARKINSON'S DISEASE	activates	gene	0.75
FERROPTOSIS	activates	gene	0.75
CANCER	therapeutic_target	gene	0.75
EXERCISE	therapeutic_target	gene	0.75
ALZHEIMER'S DISEASE	associated_with	gene	0.75
COMPLEMENT	activates	gene	0.75
ALZHEIMER	associated_with	gene	0.75
DEMENTIA	inhibits	gene	0.75
CNO	inhibits	gene	0.75
MICROGLIA	causes	gene	0.75
PARKINSON	associated_with	gene	0.75
PARKINSON	activates	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Anxiety

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Pathway Diagram

Outgoing (1157)

Incoming (1128)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

Related Papers (0)

Anxiety

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

primary-progressive-aphasia

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

Corticobasal Degeneration (CBD)

nimodipine-als

Frontotemporal Dementia (FTD) Mechanistic Pathway

Multiple System Atrophy

Alzheimer's Disease

nct07165106

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

williams-syndrome

GSK-3β in Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease

Pathway Diagram

Outgoing (1157)

Incoming (1128)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

Related Papers (0)