Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Complement: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Complement is an entity related to neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, Aging, Als. Connected to 1027 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
Complement["Complement"] -->|"activates"| Synapse["Synapse"]
Complement["Complement"] -.->|"inhibits"| Synapse_1["Synapse"]
Complement["Complement"] -->|"interacts"| Phagocytosis["Phagocytosis"]
Complement["Complement"] -->|"interacts"| Mapk["Mapk"]
Complement["Complement"] -->|"interacts"| Mtor["Mtor"]
Complement["Complement"] -->|"interacts"| Apoptosis["Apoptosis"]
HSPG2["HSPG2"] -->|"regulates"| Complement["Complement"]
EPHB4["EPHB4"] -->|"activates"| Complement["Complement"]
RHOA["RHOA"] -->|"activates"| Complement["Complement"]
CTSB["CTSB"] -->|"activates"| Complement["Complement"]
style Complement fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Synapse Loss | mediates | phenotype | 0.95 |
| Synaptic Pruning | mediates | process | 0.95 |
| Alzheimer's Disease | involved_in | disease | 0.90 |
| Glaucoma | contributes_to | disease | 0.90 |
| Neurodegeneration | mediates | process | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Glaucoma | associated_with | disease | 0.80 |
| Microglial Phagocytosis of Synapses | mediates | process | 0.75 |
| Synapse | activates | entity | 0.70 |
| Synapse | inhibits | entity | 0.70 |
| Phagocytosis | interacts_with | pathway | 0.55 |
| Mapk | interacts_with | pathway | 0.55 |
| Mtor | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Glycolysis | interacts_with | pathway | 0.55 |
| Ubiquitin-Proteasome | interacts_with | pathway | 0.55 |
| Neuron | associated_with | cell_type | 0.50 |
| Astrocyte | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1Q | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| COMPLEMENT | activates | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| COMPLEMENT | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| COMPLEMENT | associated_with | gene | 1.00 |
| COMPLEMENT | regulates | gene | 1.00 |
| COMPLEMENT | inhibits | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| MICROGLIA | regulates | gene | 1.00 |
| AMYLOID | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| PHAGOCYTOSIS | activates | gene | 1.00 |
| MICROGLIA | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| NEURON | activates | gene | 1.00 |
| Early Metastatic Epithelial Cell Clusters | involved_in | cell_type | 0.90 |
| C1Q | inhibits | gene | 0.90 |
| GENES | activates | gene | 0.90 |
| Neuroinflammation | therapeutic_target | disease | 0.90 |
| PI3K | therapeutic_target | gene | 0.90 |
| Alzheimer | regulates | disease | 0.90 |
| Cancer | activates | disease | 0.90 |
| Parkinson | activates | disease | 0.90 |
| Neurodegeneration | regulates | disease | 0.90 |
| Alzheimer | therapeutic_target | disease | 0.90 |
| EGFR | therapeutic_target | gene | 0.90 |
| COMPLEMENT | contributes_to | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
neuroinflammation | 2026-04-08 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| An integrative analysis of single-cell and bulk transcriptome and bidirectional [PMID:38179058] | Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J, | Front Immunol | 2023 | 2 |
| Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887] | Chen TY, Wu N, Sun X | Life (Basel) | 2026 | 1 |
| Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276] | Voicu V, Toader C, Șerban M, Covache-Bus | Biomedicines | 2025 | 1 |
| Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] | Han QQ, Shen SY, Liang LF, Chen XR, Yu J | Brain Behav Immun | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455] | Cornell J, Salinas S, Huang HY, Zhou M | Neural Regen Res | 2022 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Early complement genes are associated with visual system degeneration in multipl [PMID:31289819] | Fitzgerald KC, Kim K, Smith MD, Aston SA | Brain | 2019 | 1 |
| Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548] | Hong S, Beja-Glasser VF, Nfonoyim BM, Fr | Science | 2016 | 1 |
| Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: se [PMID:41853292] | Zhai X, Lin X, Zhang L, Ren Y, Miao H, M | Frontiers in immunology | 2026 | 0 |
| Proteomic Signature in Men with Central Serous Chorioretinopathy. [PMID:41641862] | Chambon C, Picard E, Zola M, Aichedo S, | Journal of proteome research | 2026 | 0 |
| Machine Learning and Blood-Targeted Proteomics Enable Early Prediction and Etiol [PMID:41683823] | Starodubtseva N, Tokareva A, Kononikhin | International journal of molec | 2026 | 0 |
| Club cell RhoA activation amplifies allergic airway inflammation by regulating e [PMID:41633491] | Tu W, Wu M, Wan R, Alphonse M, Gu W, Gho | The Journal of allergy and cli | 2026 | 0 |
| Identifying the hub genes in macrophage infiltration and verifying of the role o [PMID:41730938] | Tang L, Xu Y, Nong Z, Li F, Pan L | Scientific reports | 2026 | 0 |
| Repurposing of doxycycline as a novel therapeutic avenue for management of parki [PMID:41925933] | Ali NH, Al-Kuraishy HM, Hussain NR, Al-G | Inflammopharmacology | 2026 | 0 |
| Histological findings in follow-up liver biopsies up to 15 years after pediatric [PMID:41370831] | Quintero-Bernabeu J, Salcedo-Allende MT, | Liver Transpl | 2026 | 0 |
| Protein Corona Reprograms Hepatic Clearance Pathways of Biomimetic Nanoparticles [PMID:41944292] | He T, Fang X, Zhu L, Fan H, Qiu Y et al. | Small | 2026 | 0 |
| Mid-Term Comparison of N-Butyl Cyanoacrylate, Endovenous Laser Ablation, and Rad [PMID:41964281] | Dilek I, Kocaoglu AS, Büyükceran EU, Nay | Vasc Endovascular Surg | 2026 | 0 |