Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPHA10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ephrin Type-A Receptor 10, a receptor tyrosine kinase with predominant expression in testis and low brain expression
| Gene Symbol | EPHA10 |
| Full Name | Ephrin Type-A Receptor 10 |
| Chromosome | 4q13.3 |
| Protein Type | Receptor |
| Function | Sperm Function: EPHA10 is highly expressed in testis and is involved in sperm motility and male fertility[@matsuura2012]. |
| Primary Expression | Testis (high), Brain (low), Immune cells (moderate) |
| Molecular Weight | 105 kDa |
| Amino Acids | 954 aa |
| Exons | 17 |
| Pathways | Epigenetic, Oxidative Stress |
| UniProt ID | Q8IWU6 |
| NCBI Gene ID | 284656 |
| Ensembl ID | ENSG00000116675 |
| OMIM | 612663 |
| GeneCards | EPHA10 |
| Human Protein Atlas | EPHA10 |
| Associated Diseases | Cancer, limited brain involvement |
| Interactions | EGF, SMAD1, AXON, GENES, NEUROINFLAMMATION, OXIDATIVE STRESS |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["EPHA10"]
N1["Neuroinflammation"]
N0 -->|"activates"| N1
N2["Inflammation"]
N0 -->|"activates"| N2
N3["EGF"]
N0 -->|"activates"| N3
N4["Oxidative Stress"]
N0 -->|"activates"| N4
N5["Epigenetic"]
N0 -->|"activates"| N5
N6["SMAD1"]
N0 -->|"activates"| N6
N7["AXON"]
N0 -->|"activates"| N7
N7 -->|"activates"| N0
N6 -->|"activates"| N0
N8["GENES"]
N8 -->|"activates"| N0
N9["NEUROINFLAMMATION"]
N9 -->|"activates"| N0
N10["OXIDATIVE STRESS"]
N10 -->|"activates"| N0
N11["AND"]
N11 -->|"activates"| N0
N3 -->|"activates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 pathway
class N5 pathway
class N6 gene
class N7 gene
class N8 gene
class N9 gene
class N10 gene
class N11 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| EGF | activates | gene | 0.60 |
| SMAD1 | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| AXON | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIF | upregulates | protein | 0.90 |
| SMAD1 | activates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| AXON | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PROTEIN MISFOLDING | activates | gene | 0.60 |
| TDC | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||