gene

EPHA10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections
0Hypotheses
0Analyses
7Outgoing
10Incoming

Summary

Ephrin Type-A Receptor 10, a receptor tyrosine kinase with predominant expression in testis and low brain expression

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🧬 Gene Info
Gene SymbolEPHA10
Full NameEphrin Type-A Receptor 10
Chromosome4q13.3
Protein TypeReceptor
FunctionSperm Function: EPHA10 is highly expressed in testis and is involved in sperm motility and male fertility[@matsuura2012].
Primary ExpressionTestis (high), Brain (low), Immune cells (moderate)
Molecular Weight105 kDa
Amino Acids954 aa
Exons17
PathwaysEpigenetic, Oxidative Stress
UniProt IDQ8IWU6
NCBI Gene ID284656
Ensembl IDENSG00000116675
OMIM612663
GeneCardsEPHA10
Human Protein AtlasEPHA10
Associated DiseasesCancer, limited brain involvement
InteractionsEGF, SMAD1, AXON, GENES, NEUROINFLAMMATION, OXIDATIVE STRESS
KG Connections17 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: EPHA10 — AlphaFold Q8IWU6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

EPHA10 Gene

gene · 2474 words

EFNA1 Gene

gene · 2213 words

SMAD1 Gene

gene · 615 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["EPHA10"]
    N1["Neuroinflammation"]
    N0 -->|"activates"| N1
    N2["Inflammation"]
    N0 -->|"activates"| N2
    N3["EGF"]
    N0 -->|"activates"| N3
    N4["Oxidative Stress"]
    N0 -->|"activates"| N4
    N5["Epigenetic"]
    N0 -->|"activates"| N5
    N6["SMAD1"]
    N0 -->|"activates"| N6
    N7["AXON"]
    N0 -->|"activates"| N7
    N7 -->|"activates"| N0
    N6 -->|"activates"| N0
    N8["GENES"]
    N8 -->|"activates"| N0
    N9["NEUROINFLAMMATION"]
    N9 -->|"activates"| N0
    N10["OXIDATIVE STRESS"]
    N10 -->|"activates"| N0
    N11["AND"]
    N11 -->|"activates"| N0
    N3 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene

Outgoing (7)

TargetRelationTypeStr
Neuroinflammationactivatesdisease0.65
Inflammationactivatesdisease0.65
EGFactivatesgene0.60
SMAD1activatesgene0.60
Oxidative Stressactivatespathway0.60

Incoming (10)

SourceRelationTypeStr
PIFupregulatesprotein0.90
SMAD1activatesgene0.60
EGFactivatesgene0.60
AXONactivatesgene0.60
GENESactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found