Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TDC |
| Key Genes/Proteins | AADC, IDO1, TLR4, CSGA, GPR109A, DDC |
| Related Diseases | neuroinflammation, neurodegeneration |
| Related Pathways | insulin signaling |
Knowledge base pages for this entity
graph TD
TDC["TDC"]
TDC -->|"studied_in"| neurodegeneration["neurodegeneration"]
TDC -->|"debate_co_mention"| TLR4["TLR4"]
neuroinflammation["neuroinflammation"] -->|"co_mentioned"| TDC
AADC["AADC"] -->|"co_mentioned"| TDC
CSGA["CSGA"] -->|"debate_co_mention"| TDC
GPR109A["GPR109A"] -->|"debate_co_mention"| TDC
HDAC["HDAC"] -->|"debate_co_mention"| TDC
DDC["DDC"] -->|"debate_co_mention"| TDC| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | causes | disease | 0.55 |
| insulin signaling | participates_in | pathway | 0.55 |
| neurodegeneration | associated_with | disease | 0.51 |
| TLR4 | debate_co_mention | gene | 0.45 |
| TLR4 | co_discussed | gene | 0.40 |
| GPR109A | co_discussed | gene | 0.40 |
| AADC | co_discussed | gene | 0.40 |
| DDC | co_discussed | gene | 0.40 |
| CHRNA7 | co_discussed | gene | 0.40 |
| AGER | co_discussed | gene | 0.40 |
| CSGA | co_discussed | gene | 0.40 |
| TLR4 | co_associated_with | gene | 0.40 |
| EPHA10 | associated_with | gene | 0.35 |
| EGF | associated_with | gene | 0.35 |
| SMAD1 | associated_with | gene | 0.35 |
| als | implicated_in | disease | 0.35 |
| ms | implicated_in | disease | 0.35 |
| BDNF | associated_with | gene | 0.35 |
| alzheimer | implicated_in | disease | 0.35 |
| neurodegeneration | implicated_in | disease | 0.35 |
| parkinson | implicated_in | disease | 0.35 |
| ERK1 | associated_with | gene | 0.35 |
| ischemia | implicated_in | disease | 0.35 |
| stroke | implicated_in | disease | 0.35 |
| obesity | implicated_in | disease | 0.35 |
| PSD95 | associated_with | gene | 0.35 |
| autism | implicated_in | disease | 0.35 |
| PI3K | associated_with | gene | 0.35 |
| PTEN | associated_with | gene | 0.35 |
| FUS | associated_with | gene | 0.35 |
| huntington | implicated_in | disease | 0.35 |
| depression | implicated_in | disease | 0.35 |
| CTSD | associated_with | gene | 0.35 |
| LAMP1 | associated_with | gene | 0.35 |
| LC3 | associated_with | gene | 0.35 |
| P62 | associated_with | gene | 0.35 |
| BACE1 | associated_with | gene | 0.35 |
| APP | associated_with | gene | 0.35 |
| inflammation | implicated_in | disease | 0.35 |
| NAD | associated_with | gene | 0.35 |
| dementia | implicated_in | disease | 0.35 |
| GABA | associated_with | gene | 0.35 |
| CREB | associated_with | gene | 0.35 |
| ERK | associated_with | gene | 0.35 |
| PS1 | associated_with | gene | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-24e08335 | targets_gene | hypothesis | 0.90 |
| neuroinflammation | co_mentioned | process | 0.55 |
| AADC | co_mentioned | gene | 0.55 |
| IDO1 | causes | gene | 0.55 |
| AADC | associated_with | gene | 0.55 |
| h-24e08335 | targets | hypothesis | 0.50 |
| CSGA | debate_co_mention | gene | 0.45 |
| GPR109A | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| DDC | debate_co_mention | gene | 0.45 |
| HDAC | debate_co_mention | gene | 0.45 |
| GPR109A | co_associated_with | gene | 0.40 |
| CSGA | co_associated_with | gene | 0.40 |
| AGER | co_associated_with | gene | 0.40 |
| CHRNA7 | co_associated_with | gene | 0.40 |
| HDAC | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Restoring Neuroprotective Tryptophan Metabolism via Targeted | 0.452 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microcephaly-associated protein WDR62 supports purine metabolism by interacting [PMID:41787126] | Morris MJ, Yeap YY, Edwards JR, Chen C, | EMBO J | 2026 | 0 |
| Nonvital Pulp Therapy in Primary Teeth Using Mineral Trioxide Aggregate Obturati [PMID:41928850] | Makiguchi T, Terauchi Y, Wong K, Bogen G | Case Rep Dent | 2026 | 0 |
| Gut Microbiota and Dopamine: Producers, Consumers, Enzymatic Mechanisms, and In [PMID:41595985] | Albani G, Chellamuthu VR, Morlacchi L, Z | Bioengineering (Basel, Switzer | 2025 | 0 |
| Chemically induced reprogramming to reverse cellular aging. [PMID:37437248] | Yang JH, Petty CA, Dixon-McDougall T, Lo | Aging | 2023 | 0 |
| Mechanisms of peripheral levodopa resistance in Parkinson's disease. [PMID:35546556] | Beckers M, Bloem BR, Verbeek MM | NPJ Parkinson's disease | 2022 | 0 |
| Melatonin metabolism, signaling and possible roles in plants. [PMID:32645752] | Back K | The Plant journal : for cell a | 2021 | 0 |
| FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update [PMID:33562601] | ["Pignataro P", "Dicarlo M", "Zerlotin R | International journal of molec | 2021 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |
| The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels [PMID:30027497] | ["Afshar S", "Shahidi S", "Rohani A", "K | Psychopharmacology | 2018 | 0 |
| Melatonin and Expression of Tryptophan Decarboxylase Gene (TDC) in Herbaceous Pe [PMID:29757219] | Zhao D, Wang R, Liu D, Wu Y, Sun J, Tao | Molecules (Basel, Switzerland) | 2018 | 0 |