concept

TDC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

2Hypotheses

1Analyses

44Outgoing

15Incoming

0Experiments

1Debates

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💡 Concept Info

Name	TDC
Key Genes/Proteins	AADC, AGER, APP, BACE1, BDNF, CHRNA7
Related Diseases	als, alzheimer, autism, dementia, depression

Pathway Diagram

graph TD
    TDC["TDC"]
    TDC -->|"studied_in"| neurodegeneration["neurodegeneration"]
    TDC -->|"debate_co_mention"| TLR4["TLR4"]
    neuroinflammation["neuroinflammation"] -->|"co_mentioned"| TDC
    AADC["AADC"] -->|"co_mentioned"| TDC
    CSGA["CSGA"] -->|"debate_co_mention"| TDC
    GPR109A["GPR109A"] -->|"debate_co_mention"| TDC
    HDAC["HDAC"] -->|"debate_co_mention"| TDC
    DDC["DDC"] -->|"debate_co_mention"| TDC

Outgoing (44)

Target	Relation	Type	Str
insulin signaling	participates_in	pathway	0.55
neuroinflammation	causes	disease	0.55
neurodegeneration	associated_with	disease	0.51
TLR4	debate_co_mention	gene	0.45
AADC	co_discussed	gene	0.40
DDC	co_discussed	gene	0.40
CHRNA7	co_discussed	gene	0.40
AGER	co_discussed	gene	0.40
CSGA	co_discussed	gene	0.40
GPR109A	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40
TLR4	co_associated_with	gene	0.40
EPHA10	associated_with	gene	0.35
EGF	associated_with	gene	0.35
SMAD1	associated_with	gene	0.35
als	implicated_in	disease	0.35
ms	implicated_in	disease	0.35
BDNF	associated_with	gene	0.35
alzheimer	implicated_in	disease	0.35
parkinson	implicated_in	disease	0.35
ERK1	associated_with	gene	0.35
ischemia	implicated_in	disease	0.35
stroke	implicated_in	disease	0.35
obesity	implicated_in	disease	0.35
PSD95	associated_with	gene	0.35
autism	implicated_in	disease	0.35
PI3K	associated_with	gene	0.35
PTEN	associated_with	gene	0.35
FUS	associated_with	gene	0.35
huntington	implicated_in	disease	0.35
depression	implicated_in	disease	0.35
CTSD	associated_with	gene	0.35
LAMP1	associated_with	gene	0.35
LC3	associated_with	gene	0.35
P62	associated_with	gene	0.35
BACE1	associated_with	gene	0.35
APP	associated_with	gene	0.35
inflammation	implicated_in	disease	0.35
NAD	associated_with	gene	0.35
dementia	implicated_in	disease	0.35
GABA	associated_with	gene	0.35
CREB	associated_with	gene	0.35
ERK	associated_with	gene	0.35
PS1	associated_with	gene	0.35

Incoming (15)

Source	Relation	Type	Str
h-24e08335	targets	hypothesis	0.90
IDO1	causes	gene	0.55
AADC	associated_with	gene	0.55
neuroinflammation	co_mentioned	process	0.55
AADC	co_mentioned	gene	0.55
CSGA	debate_co_mention	gene	0.45
GPR109A	debate_co_mention	gene	0.45
neuroinflammation	debate_co_mention	process	0.45
DDC	debate_co_mention	gene	0.45
HDAC	debate_co_mention	gene	0.45
HDAC	co_discussed	gene	0.40
GPR109A	co_associated_with	gene	0.40
CSGA	co_associated_with	gene	0.40
AGER	co_associated_with	gene	0.40
CHRNA7	co_associated_with	gene	0.40

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Restoring Neuroprotective Tryptophan Metabolism via Targeted	0.612	neurodegeneration	What are the mechanisms by which gut mic
Enteric Nervous System Reprogramming via Microbial Neurotran	0.000	-	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.924

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Microcephaly-associated protein WDR62 supports purine metabolism by interacting [PMID:41787126]	Morris MJ, Yeap YY, Edwards JR, Chen C,	EMBO J	2026
Nonvital Pulp Therapy in Primary Teeth Using Mineral Trioxide Aggregate Obturati [PMID:41928850]	Makiguchi T, Terauchi Y, Wong K, Bogen G	Case Rep Dent	2026
Gut Microbiota and Dopamine: Producers, Consumers, Enzymatic Mechanisms, and In [PMID:41595985]	Albani G, Chellamuthu VR, Morlacchi L, Z	Bioengineering (Basel, Switzer	2025
Chemically induced reprogramming to reverse cellular aging. [PMID:37437248]	Yang JH, Petty CA, Dixon-McDougall T, Lo	Aging	2023
Mechanisms of peripheral levodopa resistance in Parkinson's disease. [PMID:35546556]	Beckers M, Bloem BR, Verbeek MM	NPJ Parkinson's disease	2022
Melatonin metabolism, signaling and possible roles in plants. [PMID:32645752]	Back K	The Plant journal : for cell a	2021
FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update [PMID:33562601]	["Pignataro P", "Dicarlo M", "Zerlotin R	International journal of molec	2021
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020
The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels [PMID:30027497]	["Afshar S", "Shahidi S", "Rohani A", "K	Psychopharmacology	2018
Melatonin and Expression of Tryptophan Decarboxylase Gene (TDC) in Herbaceous Pe [PMID:29757219]	Zhao D, Wang R, Liu D, Wu Y, Sun J, Tao	Molecules (Basel, Switzerland)	2018

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning TDC in their description or question text

No additional research found