EGF

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Epidermal Growth Factor gene - a neurotrophic factor implicated in neuronal survival, neuroprotection, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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flowchart TD
    EGF(["EGF"])
    Cancer["Cancer"]
    Als["Als"]
    Tumor["Tumor"]
    CANCER(["CANCER"])
    Nrf2["Nrf2"]
    AKT(["AKT"])
    EGFR(["EGFR"])
    RAS(["RAS"])
    Carcinoma["Carcinoma"]
    Egfr_Signaling["Egfr Signaling"]

    EGF -->|"activates"| Cancer
    EGF -->|"activates"| Als
    EGF -->|"activates"| Tumor
    CANCER -->|"activates"| EGF
    EGF -->|"expressed in"| Tumor
    Nrf2 -->|"upregulates"| EGF
    EGF -->|"activates"| AKT
    EGFR -->|"activates"| EGF
    RAS -->|"activates"| EGF
    EGF -->|"interacts with"| Als
    EGF -->|"activates"| Carcinoma
    EGF -->|"therapeutic target"| Cancer
    EGF -->|"activates"| EGFR
    EGF -->|"interacts with"| EGFR
    EGF -->|"activates"| Egfr_Signaling

    style EGF fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0