gene

EGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1007Connections

6Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Epidermal Growth Factor gene - a neurotrophic factor implicated in neuronal survival, neuroprotection, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	EGF
Full Name	Epidermal Growth Factor
Aliases	Epidermal Growth Factor gene
Chromosome	4q25
Function	is a type I transmembrane protein that can be proteolytically cleaved at multiple sites to release the mature growth factor.
Molecular Weight	6.2 kDa
Amino Acids	53 aa
Exons	24
Pathways	MAPK, PI3K
UniProt ID	P01133
NCBI Gene ID	1167
Ensembl ID	ENSG00000138798
OMIM	131530
GeneCards	EGF
Human Protein Atlas	EGF
Associated Diseases	Aging, Als, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, ALDH1L1, ALZHEIMER'S DISEASE
KG Connections	1006 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EGF — AlphaFold P01133 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

company · 2020 words

→

PD EGFR and Receptor Tyrosine Kinase Therapeutic Companies

company · 1817 words

→

Pathway Diagram

flowchart TD
    EGF(["EGF"])
    Cancer["Cancer"]
    Als["Als"]
    Tumor["Tumor"]
    CANCER(["CANCER"])
    Nrf2["Nrf2"]
    AKT(["AKT"])
    EGFR(["EGFR"])
    RAS(["RAS"])
    Carcinoma["Carcinoma"]
    Egfr_Signaling["Egfr Signaling"]

    EGF -->|"activates"| Cancer
    EGF -->|"activates"| Als
    EGF -->|"activates"| Tumor
    CANCER -->|"activates"| EGF
    EGF -->|"expressed in"| Tumor
    Nrf2 -->|"upregulates"| EGF
    EGF -->|"activates"| AKT
    EGFR -->|"activates"| EGF
    RAS -->|"activates"| EGF
    EGF -->|"interacts with"| Als
    EGF -->|"activates"| Carcinoma
    EGF -->|"therapeutic target"| Cancer
    EGF -->|"activates"| EGFR
    EGF -->|"interacts with"| EGFR
    EGF -->|"activates"| Egfr_Signaling

    style EGF fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (675)

Target	Relation	Type	Str
EGF	encodes	protein	0.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Tumor	expressed_in	disease	0.95
AKT	activates	gene	0.90
Cancer	therapeutic_target	disease	0.85
PIF	inhibits	protein	0.85
Carcinoma	activates	disease	0.85
Als	interacts_with	disease	0.85
EGFR	activates	protein	0.82
neural stem cells	regulates	cell_type	0.80
stem cells	supports	cell_type	0.80
neural stem cells	activates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
Neuroregulin Signaling	activates	pathway	0.80
stem cells	expressed_in	cell_type	0.80
EGFR	interacts_with	gene	0.80
Egfr Signaling	activates	pathway	0.80
Inflammation	activates	disease	0.75
Cancer	expressed_in	disease	0.75
Cancer	regulates	disease	0.75
Cancer	associated_with	disease	0.75
Tumor	therapeutic_target	disease	0.75
Glioblastoma	activates	disease	0.75
ULK1	activates	gene	0.70
PDGF	associated_with	gene	0.70
NFKB	activates	gene	0.70
ULK1	interacts_with	gene	0.70
PDK1	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Mapk	activates	pathway	0.70
endothelial cells	expressed_in	cell_type	0.70
JAK-STAT signaling	participates_in	pathway	0.70
Receptor Tyrosine Kinase	activates	pathway	0.70
Erk Signaling	activates	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
CANCER	activates	gene	0.70
Endocytosis	activates	pathway	0.70
MYC	activates	gene	0.70
SRC	activates	gene	0.70
PI3K	regulates	gene	0.70
EGFR	expressed_in	gene	0.70
EGFR	therapeutic_target	gene	0.70
Neurodegeneration	regulates	disease	0.65
Stroke	regulates	disease	0.65
Senescence	activates	disease	0.65
Aging	associated_with	disease	0.65
Senescence	expressed_in	disease	0.65
Ms	regulates	disease	0.65

Incoming (332)

Source	Relation	Type	Str
EGF	encodes	gene	0.00
EGFR	associated_with	gene	1.00
CANCER	activates	gene	1.00
Nrf2	upregulates	entity	0.95
NFE2L2	upregulates	gene	0.91
NRF2	upregulates	gene	0.90
EGFR	activates	gene	0.90
RAS	activates	gene	0.90
ERK	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
CCL2	regulates	gene	0.70
BECN1	regulates	gene	0.70
AMPK	activates	gene	0.70
ASTROCYTE	expressed_in	cell_type	0.70
CREB	interacts_with	gene	0.70
ATG7	activates	gene	0.70
CREB	regulates	gene	0.70
CANCER	associated_with	gene	0.70
BAX	expressed_in	gene	0.70
ENDOSOMES	activates	gene	0.70
GENES	expressed_in	gene	0.70
EGFR	therapeutic_target	gene	0.70
PI3K	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
YAP	activates	gene	0.70
IL-6	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
KRAS	activates	gene	0.70
HIPPO	activates	gene	0.70
CANCER	regulates	gene	0.70
MIRNAS	interacts_with	gene	0.70
rapamycin	targets	drug	0.70
STEM CELLS	activates	cell_type	0.65
NAFLD	regulates	disease	0.65
NRF2	activates	protein	0.64
CALCOCO2	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VEGF-family genetic control of vascular-neuronal coupling in	0.626	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Cell-state stratification is required to resolve VEGF Family	0.612	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Cerebral VSMC foam cells induce pericyte detachment via PDGF	0.473	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Astrocytic MEGF10 Upregulation for Selective Synaptic Engulf	0.354	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (1)

Scientific analyses that reference this entity

VEGF Family GWAS Signals and Cerebrovascular-Neuronal Coupling in AD Hippocampus

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do VEGF family gene variants identified by single-cell GWAS analysis alter c

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

Related Research

Hypotheses and analyses mentioning EGF in their description or question text

Astrocytic MEGF10 Upregulation for Selective Synaptic Engulfment Control

Score: 0.354 · connectomics · 2026-04-26

Astrocytes express multiple phagocytic receptors including MEGF10 (multiple EGF-like domains 10) that enable direct syna

EGF

Understanding Entity Pages

Summary

Wiki Pages (21)

EGF Gene

VEGF/Angiogenesis Pathway in Neurodegeneration

EGFR Signaling in Parkinson's Disease

VEGF Signaling and Cerebral Angiogenesis in Neurodegeneration

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

PD EGFR and Receptor Tyrosine Kinase Therapeutic Companies

NEURD1 - N-terminal EGF Like Domain Calcium Binding Protein 1

VEGF and Angiogenesis Dysregulation in CBS/PSP

EGFR — Epidermal Growth Factor Receptor

PD EGFR Signaling Therapy Companies

Parkinson's Disease EGFR Signaling Therapy Companies

Parkinson's Disease EGFR Signaling Therapy Companies

Pericyte PDGFR/VEGFR Modulator Therapy for Neurodegeneration

VEGF Angiogenesis Therapy for Parkinson's Disease

VEGFR1 (FLT1) Protein

Parkinson's Disease VEGF/Angiogenic Signaling Therapy Companies

Vascular Endothelial Growth Factor (VEGF)

VEGF (Vascular Endothelial Growth Factor)

VEGF and Angiogenesis Therapy

VEGFA — Vascular Endothelial Growth Factor A

VEGFB Protein