Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPHA4PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ephrin type-A receptor 4 (EphA4) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neuronal development, synaptic plasticity, and regenerative responses in the central nervous system[@eph2020].
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| Gene Symbol | EPHA4PROTEIN |
| Full Name | EphA4 |
| Chromosome | 2q36.1 |
| Protein Type | Protein |
| Function | is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neuronal development, synaptic plasticity, and regenerative responses in the central nervous system[@eph2020]. |
| Primary Expression | injured tissues and tumors - Bidirectional signaling: Both forward (receptor→ligand cell) and reverse (ligand→receptor cell) signaling occur[@ephr |
| Amino Acids | 986 aa |
| UniProt ID | Search UniProt |
| GeneCards | EPHA4PROTEIN |
| Human Protein Atlas | EPHA4PROTEIN |
| Brain regions | High expression in hippocampus, cortex, cerebellum, and spinal cord |
| Cell types | Neurons, astrocytes, and certain glial cells |
| Developmental regulation | Peak expression during embryonic development and early postnatal periods |
| Adult brain | Maintained expression in regions of ongoing plasticity[@epha2021] |
| Extracellular domain | Contains a ligand-binding domain, a cysteine-rich region, and two fibronectin type III repeats |
| Associated Diseases | Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Inflammation |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ASTROCYTE, ASTROCYTES, AXON |
| KG Connections | 68 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EPHA4PROTEIN["EPHA4PROTEIN"]
neurodegeneration["neurodegeneration"]
EPHA4PROTEIN -->|"implicated_in"| neurodegeneration
style EPHA4PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EPHA4PROTEIN in their description or question text
No additional research found