Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Dementia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Dementia is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 1596 entities in the SciDEX knowledge graph.
| Associated Genes | TGM2, JUN, AQP4, UNC13A, OPTN, VCP, SQSTM1, TIA1 |
| Therapeutic Agents | Cholinesterase Inhibitors, Memantine, Butyrate, AMS-17, D-520 |
| KG Connections | 2605 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
CTSB["CTSB"] -->|"activates"| Dementia["Dementia"]
C1QA["C1QA"] -->|"activates"| Dementia["Dementia"]
SPP1["SPP1"] -->|"activates"| Dementia["Dementia"]
GRN["GRN"] -->|"activates"| Dementia["Dementia"]
style Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Alzheimer | biomarker_for | disease | 1.00 |
| Alzheimer | causes | disease | 1.00 |
| Aging | biomarker_for | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Als | associated_with | disease | 0.95 |
| Aging | associated_with | disease | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| Als | biomarker_for | disease | 0.95 |
| Low- and Middle-Income Countries | associated_with | phenotype | 0.95 |
| Brain Aging | associated_with | process | 0.90 |
| Prevention | involved_in | process | 0.90 |
| Diagnosis | involved_in | process | 0.90 |
| Global Dementia Rates | correlates_with | phenotype | 0.90 |
| Nf-Κb | activates | pathway | 0.90 |
| Alzheimer Disease | associated_with | disease | 0.88 |
| Alzheimer | therapeutic_target | disease | 0.85 |
| Alzheimer | activates | disease | 0.85 |
| Als | treats | disease | 0.85 |
| Viral Vector Gene Therapy | treats | drug | 0.85 |
| Socioeconomic Disparities | correlates_with | phenotype | 0.85 |
| Differential Diagnosis | involved_in | process | 0.85 |
| Treatment Options | involved_in | process | 0.85 |
| Neuropsychometric Tools | biomarker_for | biomarker | 0.80 |
| Inflammasome | activates | pathway | 0.80 |
| Stem Cell | activates | pathway | 0.80 |
| Differentiation | therapeutic_target | pathway | 0.80 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Mapk | therapeutic_target | pathway | 0.80 |
| Alzheimer | interacts_with | disease | 0.75 |
| Als | inhibits | disease | 0.75 |
| Aging | activates | disease | 0.75 |
| Alzheimer | implicated_in | disease | 0.75 |
| Phagocytosis | activates | pathway | 0.70 |
| Ferroptosis | associated_with | pathway | 0.70 |
| Lipid Metabolism | regulates | pathway | 0.70 |
| Epigenetic | therapeutic_target | pathway | 0.70 |
| Proteasome | activates | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Ubiquitin-Proteasome | activates | pathway | 0.70 |
| Mtor | activates | pathway | 0.70 |
| Blood-Brain Barrier | contributes_to | pathway | 0.70 |
| Blood-Brain Barrier | biomarker_for | pathway | 0.70 |
| Mapk | activates | pathway | 0.70 |
| Autophagy | therapeutic_target | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | associated_with | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| NFL | biomarker_for | gene | 1.00 |
| APP | activates | gene | 1.00 |
| SNCA | associated_with | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | contributes_to | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| MICROGLIA | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| TAU | associated_with | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| TAU | therapeutic_target | gene | 1.00 |
| NEUROINFLAMMATION | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| ALZHEIMER DISEASE | biomarker_for | gene | 1.00 |
| TAU | biomarker_for | gene | 1.00 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| DEMENTIA | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | causes | gene | 1.00 |
| ALZHEIMER | causes | gene | 1.00 |
| DEMENTIA | causes | gene | 1.00 |
| TAU | causes | gene | 1.00 |
| DEMENTIA | inhibits | gene | 1.00 |
| DEMENTIA | activates | gene | 1.00 |
| NEURON | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||