Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FOXP3/TGFB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| NR3C1 | debate_co_mention | gene | 0.45 |
| NR3C1/CRH/TNFA | debate_co_mention | gene | 0.45 |
| PDGFRB | debate_co_mention | gene | 0.45 |
| PPARGC1A/PRKAA1 | co_associated_with | gene | 0.40 |
| NR3C1/CRH/TNFA | co_associated_with | gene | 0.40 |
| PDGFRB/ANGPT1 | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:FOXP3/TGFB1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLOCK/ULK1 | debate_co_mention | gene | 0.45 |
| CRH | debate_co_mention | gene | 0.45 |
| DRD2 | debate_co_mention | gene | 0.45 |
| DRD2/SNCA | debate_co_mention | gene | 0.45 |
| CLOCK/ULK1 | co_associated_with | gene | 0.40 |
| DRD2/SNCA | co_associated_with | gene | 0.40 |
| CHR2/BDNF | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:FOXP3/TGFB1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ocular Immune Privilege Extension | 0.474 | neurodegeneration | Digital biomarkers and AI-driven early d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Myocardial Milieu Favors Local Differentiation of Regulatory T Cells. [PMID:36744467] | Delgobo M, Weiß E, Ashour D, Richter L, | Circ Res | 2023 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| [Not Available]. [PMID:29176281] | Unknown | Nihon Rinsho Men'eki Gakkai ka | 2017 | 1 |
| Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of col [PMID:27111280] | Saito T, Nishikawa H, Wada H, Nagano Y, | Nat Med | 2016 | 1 |
| Impact of TGF-β1 on tumor immune microenvironment and prognosis in colorectal li [PMID:41386216] | Wang S, He J, Liao Y, Li W, Zhang W, Kan | Cancer treatment and research | 2026 | 0 |
| An integrative analysis of genetic factors reveals dysregulation of cytokines, i [PMID:41593604] | Patidar P, Prakash T | Thrombosis journal | 2026 | 0 |
| TGFβ1 and SMAD3 Expression Are Associated With Survival After the Immune Checkpo [PMID:41187938] | Seto Z, Inomata M, Noguchi A, Kado T, Mu | Cancer reports (Hoboken, N.J.) | 2025 | 0 |
| Immunomodulatory and anti-inflammatory effects of agave fructans in atopic derma [PMID:41409292] | Rios-Carlos M, Jiménez M, Cervantes-Garc | Frontiers in immunology | 2025 | 0 |
| Assessment and Characterization of Induced Alloantigen-Specific Regulatory T Cel [PMID:41303440] | Bulygin A, Fisher M, Kurilin V, Alrhmoun | International journal of molec | 2025 | 0 |
| Peritumoral administration of immunomodulatory antibodies as a triple combinatio [PMID:38296598] | ["Wright Q", "Sinha D", "Wells J", "Fraz | Journal for immunotherapy of c | 2024 | 0 |
| Development and validation of prediction rules to target care intensification in [PMID:32546511] | ["Campbell H", "Murata A", "Charlton G", | BMJ health & care informatics | 2020 | 0 |
| Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633] | ["Corces M", "Shcherbina A", "Kundu S", | Nature genetics | 2020 | 0 |
| HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 targ [PMID:30962285] | ["Hu T", "Schreiter F", "Bagchi R", "Tat | The Journal of biological chem | 2019 | 0 |
| Layer-specific integration of locomotion and sensory information in mouse barrel [PMID:31197148] | ["Ayaz A", "St\u00e4uble A", "Hamada M", | Nature communications | 2019 | 0 |
| Emission factors of atmospheric and climatic pollutants from crop residues burni [PMID:29652225] | ["Santiago-De La Rosa N", "Gonz\u00e1lez | Journal of the Air & Waste Man | 2018 | 0 |
| Hematology in 2010: New therapies and standard of care in oncology. [PMID:21278770] | ["DeVita V", "Canellos G"] | Nature reviews. Clinical oncol | 2011 | 0 |
| Macrophage activation syndrome in rheumatic disease: what is the role of the ant [PMID:18295734] | ["Behrens E"] | Autoimmunity reviews | 2008 | 0 |
| Vascular risk factors and diabetic neuropathy. [PMID:15673800] | ["Tesfaye S", "Chaturvedi N", "Eaton S", | The New England journal of med | 2005 | 0 |