Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FRDA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FRDA |
| Function | encodes a small mitochondrial protein that plays a critical role in iron-sulfur cluster (Fe-S) biogenesis, mitochondrial energy production, and cellular iron homeostasis. |
| Molecular Weight | ~14 kDa (precursor), ~8 kDa (mature) |
| Amino Acids | 210 aa |
| Ensembl ID | ENSG00000165060 |
| GeneCards | FRDA |
| Human Protein Atlas | FRDA |
| Associated Diseases | ALS, Ataxia, neurodegeneration |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FRDA["FRDA"]
Ataxia["Ataxia"]
FXN["FXN"]
AND["AND"]
neurodegeneration["neurodegeneration"]
FRDA -->|"causes"| Ataxia
FRDA -->|"causes"| FXN
FRDA -->|"contributes to"| AND
FRDA -->|"implicated in"| neurodegeneration
style FRDA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Ataxia fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
style FXN fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style AND fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.70 |
| Ataxia | causes | disease | 0.65 |
| FXN | causes | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FXN | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||