gene

FXN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FXN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

37Outgoing

26Incoming

Summary

FXN is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Migraine. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FXN
Full Name	Frataxin
Chromosome	9q21.11
Function	Within this complex, frataxin
Primary Expression	Dorsal root ganglia, Spinal cord, Cerebellum, Heart, Pancreas, Liver
Molecular Weight	14 kDa
Amino Acids	210 aa
Pathways	Autophagy, Mitophagy
UniProt ID	Q16595
Ensembl ID	ENSG00000165060
OMIM	606829
GeneCards	FXN
Human Protein Atlas	FXN
Symbol [@expression2024] FXN [@fox2019] [@delatycki2019] [@ncbi] Full Name [@omim] Frataxin [@proteins] [@httpswwwncbinlmnihgovgene] [@httpsensemblorghomosapiensgenesummarygensg] Chromosome [@httpsomimorgentry] 9q21.11 [@httpswwwuniprotorguniprotq] [@fxn] [@fxna] NCBI Gene [@httpswwwcurefaorg] 2395 Ensembl	ENSG00000165060
Associated Diseases	Ataxia, Friedreich's Ataxia, Migraine
Interactions	MITOCHONDRIA, C-MYC, AND, MYC, HMOX1, TFAM
KG Connections	63 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FXN — AlphaFold Q16595 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FXN["<b>FXN</b>"]
    Migraine{"Migraine"}
    FXN -->|"associated with"| Migraine
    EPHA5["EPHA5"]
    FXN -->|"associated with"| EPHA5
    EP300["EP300"]
    FXN -->|"associated with"| EP300
    NLGN2["NLGN2"]
    FXN -->|"associated with"| NLGN2
    CDK4["CDK4"]
    FXN -->|"associated with"| CDK4
    CHD4["CHD4"]
    FXN -->|"associated with"| CHD4
    HMGCR["HMGCR"]
    FXN -->|"associated with"| HMGCR
    TGFB3["TGFB3"]
    FXN -->|"associated with"| TGFB3
    neurodegeneration["neurodegeneration"]
    FXN -->|"implicated in"| neurodegeneration
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| FXN
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| FXN
    TP53["TP53"]
    TP53 -->|"associated with"| FXN
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| FXN
    style FXN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Friedreich's Ataxia	causes	disease	0.90
Iron Sulfur Cluster Biogenesis	participates_in	biological_process	0.80
Migraine	associated_with	disease	0.65
Ataxia	causes	disease	0.65
Obesity	regulates	disease	0.65
Cancer	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Ms	regulates	disease	0.65
Ataxia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Diabetes	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cardiomyopathy	therapeutic_target	disease	0.65
EPHA5	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NLGN2	associated_with	gene	0.60
CDK4	associated_with	gene	0.60
CHD4	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
TGFB3	associated_with	gene	0.60
GAA	associated_with	entity	0.60
MFN1	regulates	gene	0.60
FIS1	regulates	gene	0.60
GAA	causes	gene	0.60
FRDA	causes	gene	0.60
AND	contributes_to	gene	0.60
MITOPHAGY	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
C-MYC	activates	gene	0.60
Autophagy	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
AND	interacts_with	gene	0.60
App	therapeutic_target	protein	0.60
GAA	co_discussed	gene	0.50

Incoming (26)

Source	Relation	Type	Str
Hypoxia	associated_with	biological_process	0.80
Proteostasis Networks	modulates	biological_process	0.70
PITRM1	regulates	enzyme	0.70
KCNK5	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
NR1D1	associated_with	gene	0.60
FRDA	causes	gene	0.60
MYC	activates	gene	0.60
DRP1	regulates	gene	0.60
HMOX1	activates	gene	0.60
TFEB	regulates	gene	0.60
TFAM	activates	gene	0.60
CALCINEURIN	regulates	gene	0.60
NRF1	activates	gene	0.60
BNIP3	regulates	gene	0.60
SIRT1	activates	gene	0.60
MFN2	regulates	gene	0.60
MIEF2	regulates	gene	0.60
PINK1	regulates	gene	0.60
GAA	causes	gene	0.60
LYSOSOME	regulates	gene	0.60
NAD	activates	gene	0.60
CANCER	regulates	gene	0.60
AND	activates	gene	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FXN

Understanding Entity Pages

Summary

Wiki Pages (21)

FXN — Frataxin

dna-damage-repair

Trinucleotide Repeat Expansion Disorders

Iron Homeostasis Dysregulation in Neurodegeneration

Friedreich's Ataxia

ataxia-telangiectasia

Cerebellar Degeneration Pathway

spinocerebellar-ataxia

inferior-olivary-nucleus

MELAS Syndrome (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes)

crispr-gene-editing

DNAJC20 Gene

Neurons in Dentatorubral-Pallidoluysian Atrophy

Cerebellar Purkinje Cells in Ataxia

Cerebellum

FRDA1 Gene - Frataxin (FXN)

MIEF2 — Mitochondrial Elongation Factor 2 (MiD50)

fer2

CARS1