Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FZD10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Page for FZD10 Gene - Frizzled Class Receptor 10 involved in Wnt signaling and neurodegeneration
| Gene Symbol | FZD10 |
| Full Name | Frizzled Class Receptor 10 |
| Aliases | Page for FZD10 Gene |
| Chromosome | 12q14.1 |
| Protein Family | Class Frizzled GPCR (7-TM receptor) |
| Function | is a member of the Frizzled family of seven-transmembrane G protein-coupled receptors that serve as primary receptors for Wnt ligands. |
| Primary Expression | neural stem cells, developing neurons, and select mature neuronal populations, where it regulates neurogenesis, neuronal differentiation, and synaptic |
| Molecular Weight | 77 kDa |
| Amino Acids | 695 aa |
| Pathways | Wnt, Wnt pathway, Wnt signaling |
| UniProt ID | Q9ULW2 |
| NCBI Gene ID | 8372 |
| Ensembl ID | ENSG00000111432 |
| OMIM | 605548 |
| GeneCards | FZD10 |
| Human Protein Atlas | FZD10 |
| Associated Diseases | Synovial Sarcoma, Cancer, Alzheimer's Disease, Parkinson's Disease |
| Interactions | β-catenin, YAP1 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
FZD10(["FZD10"])
__catenin(["beta-catenin"])
YAP1(["YAP1"])
lenvatinib_resistance("lenvatinib resistance")
METTL3(["METTL3"])
neurodegeneration["neurodegeneration"]
FZD10 -->|"activates"| __catenin
FZD10 -->|"activates"| YAP1
FZD10 -->|"promotes"| lenvatinib_resistance
METTL3 -->|"regulates"| FZD10
FZD10 -->|"implicated in"| neurodegeneration
style FZD10 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| β-catenin | activates | protein | 0.95 |
| YAP1 | activates | protein | 0.95 |
| lenvatinib resistance | promotes | phenotype | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| METTL3 | regulates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||