protein

METTL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METTL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

393Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

METTL3 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with ALS, Aging, Als. Connected to 197 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	METTL3
Aliases	m6A Methyltransferase
Function	METTL3 (Methyltransferase Like 3) is the catalytic core component of the N6-methyladenosine (m6A) methyltransferase complex.
Subcellular Localization	</strong> Nucleus, cytosol</div> <div class="infobox-row"><strong>Protein Fami
Molecular Weight	64.6 kDa
Pathways	Autophagy, Akt, Pi3K, Wnt, Complement
GeneCards	METTL3
Human Protein Atlas	METTL3
Associated Diseases	ALS, Aging, Alzheimer's disease, Cancer, Ftd
Known Drugs/Compounds	metformin, levodopa
Interactions	PPARGC1A, ACSL5, BAMBI, FERROPTOSIS, CANCER, GENES
KG Connections	392 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    METTL3["METTL3"]
    METTL3 -->|"regulates"| proteostasis["proteostasis"]
    METTL3 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    METTL3 -->|"target for"| Als["Als"]
    METTL3 -->|"target for"| Aging["Aging"]
    METTL3 -->|"target for"| Ms["Ms"]
    METTL3 -->|"target for"| Cancer["Cancer"]
    METTL3 -->|"inhibits"| Carcinoma["Carcinoma"]
    ELAVL2["ELAVL2"] -->|"target for"| METTL3
    CLPP["CLPP"] -->|"target for"| METTL3
    PI3K["PI3K"] -->|"target for"| METTL3
    MTOR["MTOR"] -->|"target for"| METTL3
    BDNF["BDNF"] -->|"target for"| METTL3
    HNRNPA2B1["HNRNPA2B1"] -->|"target for"| METTL3
    GENES["GENES"] -->|"target for"| METTL3
    IGF2BP1["IGF2BP1"] -->|"target for"| METTL3
    ACSL5["ACSL5"] -->|"inhibits"| METTL3
    BAMBI["BAMBI"] -->|"inhibits"| METTL3

Outgoing (248)

Target	Relation	Type	Str
Cancer	activates	disease	0.95
N6-Methyladenosine	regulates	compound	0.95
m6A modification	mediates	process	0.95
m6A methylation	regulates	process	0.95
Parkinson'S Disease	risk_factor_for	disease	0.95
FZD10	regulates	gene	0.90
Parkinson's Disease	risk_factor_for	disease	0.90
dopaminergic neurons	expressed_in	cell_type	0.90
Substantia Nigra	expressed_in	brain_region	0.90
PPARGC1A	downregulates	gene	0.85
Alternative Splicing	regulates	process	0.85
Viral Gene Expression	regulates	process	0.85
ALZHEIMER'S DISEASE	modulates	disease	0.80
NEUROINFLAMMATION	modulates	process	0.80
AUTOPHAGY	modulates	process	0.80
Translation Fidelity	regulates	process	0.80
Alzheimer's disease	implicated_in	disease	0.80
Autophagy	activates	pathway	0.80
CANCER	activates	gene	0.80
Tumor	associated_with	disease	0.75
Als	inhibits	disease	0.75
Translation Fidelity	modulates	process	0.75
proteostasis	regulates	process	0.70
Apoptosis	inhibits	pathway	0.70
RNA	regulates	gene	0.70
Neurodegeneration	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Lymphoma	activates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Ms	associated_with	disease	0.65
ALS	associated_with	disease	0.65
ALS	contributes_to	disease	0.65

Incoming (145)

Source	Relation	Type	Str
E6	degrades	protein	0.95
HPV E6	degrades	protein	0.95
E6AP	mediates	protein	0.90
β-catenin	upstream_of	protein	0.85
AUTOPHAGY	activates	gene	0.70
ELAVL2	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
WTAP	associated_with	gene	0.60
HNRNPA2B1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
ACSL5	inhibits	gene	0.60
BAMBI	inhibits	gene	0.60
PPARGC1A	inhibits	gene	0.60
AKT	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
ACSL5	activates	gene	0.60
BAMBI	activates	gene	0.60
VHL	regulates	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
PIK3R3	regulates	gene	0.60
CANCER	regulates	gene	0.60
C1Q	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
IGF2BP2	activates	gene	0.60
PRKN	activates	gene	0.60
AMBRA1	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
FERROPTOSIS	activates	gene	0.60
SLC7A11	activates	gene	0.60
HK2	expressed_in	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
C1Q/C3	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

METTL3

Understanding Entity Pages

Summary

Wiki Pages (20)

Epigenetic Alterations in Alzheimer's Disease

Epigenetic Mechanisms in Alzheimer's Disease

PTBP2 - Polypyrimidine Tract Binding Protein 2

Epigenetic Alterations in Alzheimer's Disease

RNA Stability and Decay

FZD10 Gene

Epigenetics in Amyotrophic Lateral Sclerosis

Transcriptional Dysregulation in Neurodegeneration

RNA Metabolism Dysfunction in Corticobasal Syndrome

CBS Epigenetic Mechanisms

AHCYL1 Gene

VIRMA (KIAA1429) in Neurodegeneration

Section 183: Epitranscriptomics and RNA Modifications in CBS/PSP

payload-ythdf-m6a-reader-modulation-therapy

Epitranscriptomics and RNA Modifications in CBS/PSP

VIRMA (KIAA1429)

m6A RNA Methylation Modulation Therapy for Neurodegeneration

m6A RNA Methylation (Epitranscriptomics) in Neurodegeneration