Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about β-catenin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-373fac84b5 | targeted_by | hypothesis | 1.00 |
| MEK | upstream_of | protein | 0.85 |
| METTL3 | upstream_of | protein | 0.85 |
| F-actin polymerization | activates | process | 0.70 |
| tunneling nanotube formation | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-373fac84b5 | targets | hypothesis | 1.00 |
| FZD10 | activates | gene | 0.95 |
| Cx43 C-terminal domain | binds | protein | 0.90 |
| 37009120 | encodes | paper | 0.90 |
| GSK-3Β | phosphorylates | gene | 0.85 |
| WNT | interacts_with | gene | 0.80 |
| TDP-43 | regulates | protein | 0.80 |
| HSP90α | activates | protein | 0.80 |
| LRP1 | regulates | gene | 0.80 |
| TDP-43 | associated_with | protein | 0.80 |
| WNT | inhibits | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Wnt/β-catenin Pathway Restoration | 0.686 | - | Blood-brain barrier tight junction disru |
| NF-κB/β-Catenin Competitive Binding Modulation | 0.000 | - | Blood-brain barrier tight junction disru |
Scientific analyses that reference this entity
cell biology | 2026-04-12 | 2 hypotheses Top: 0.724
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning β-catenin in their description or question text
No additional research found